DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response
Author
Yang L.
Jing Y.
Wang W.
Ying W.
Lin L.
Chang J.
Luo L.
Kang D.
Jiang P.
Liu J.
Chen Q.
Miller H.
Herrada A.A.
Kubo M.
Sun J.
Liu C.
Abstract
Dedicator of cytokinesis 2 (DOCK2) is essential for the B cell differentiation, BCR signaling and humoral immune response. However, the role of DOCK2 in the memory response of B cell is unknown. By using two DOCK2 deficient patients, we found that the memory B cells were decreased and the early activation of DOCK2 deficient memory B cells was abolished to the degree of naïve B cells due to the decreased expression of CD19 and CD21 mechanistically. Interestingly the expression of LEF-1, a negative regulator of CD21, was increased in DOCK2 deficient B cells. This was linked to the increased expression of HIF-1α and cell metabolism, which in turn affected the ER structure. Finally, the reduction of memory B cells in DOCK2 patients was due to the increased apoptosis, which might be related with the increased metabolism. © 2020
Collections
Related items
Showing items related by title, author, creator and subject.
-
Article
Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease (2020)
Ettcheto M.; Abad S.; Petrov D.; Pedrós I.; Busquets O.; Sánchez-López E.; Casadesús G.; Beas-Zarate C.; Carro E.; Auladell C.; ... (Humana Press Inc., 2018) -
Review
Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells (2020)
Baez-Jurado E.; Rincón-Benavides M.A.; Hidalgo-Lanussa O.; Guio-Vega G.; Ashraf G.M.; Sahebkar A.; Echeverria V.; Garcia-Segura L.M.; Barreto G.E. (Academic Press Inc., 2019) -
Article
Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation (2020)
Araos P.; Prado C.; Lozano M.; Figueroa S.; Espinoza A.; Berger T.; Mak T.W.; Jaisser F.; Pacheco R.; Michea L.; ... (Lippincott Williams and Wilkins, 2019)