Study of lymphocyte subpopulations and intrathecal secretion in patients with definite multiple sclerosis [Estudo das subpopulações de linfócitos e secreção intratecal em pacientes com esclerose múltipla definida]
Multiple sclerosis is an inflammatory demyelinating autoimmune disease that affects the brain and spinal cord. The aim of the study was to quantify lymphocyte subpopulations in cerebrospinal fluid and blood of patients diagnosed with multiple sclerosis and in patients whit degenerative diseases not (control) in order to find some relationships between them that make it possible to differentiate the immune status of patients in each group. This work was jointly carried out with Hospital Universitario Virgen Macarena in Seville during 2008, 2009 and 2010. It is a descriptive, transversal and cohort study. The selected population is composed of 142 subjects who were subjected to lumbar puncture and a blood sample. Group 1 (n=70), control, Group 2 (n=53), patients with relapsing remitting multiple sclerosis, Group 3 (n=5), patients with primary type progressive multiple sclerosis, and Group 4 (n=14) patients with isolated neurological syndrome. The results show an increase in CSF B cells in MS patients suggesting an increase in focal inflammatory activity in the CNS. Regarding NKCD8, reduced total levels of NK and NKCD8 regarding controls were observed, and it showed an increased IgG index value in patients with RRMS.
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ArticleSerrano-Pertierra E.; Blanco-Gelaz M.A.; Oliva-Nacarino P.; Martínez-Camblor P.; Villafani J.; López-Larrea C.; Cernuda-Morollón E. (Elsevier B.V., 2015)
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