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dc.contributor.authorTomé-Carneiro J.
dc.contributor.authorCarmen Crespo M.
dc.contributor.authorBurgos-Ramos E.
dc.contributor.authorTomas-Zapico C.
dc.contributor.authorGarcía-Serrano A.
dc.contributor.authorCastro-Gómez P.
dc.contributor.authorVenero C.
dc.contributor.authorPereda-Pérez I.
dc.contributor.authorBaliyan S.
dc.contributor.authorValencia A.
dc.contributor.authorFontecha J.
dc.contributor.authorDávalos A.
dc.contributor.authorVisioli F.
dc.date.accessioned2020-09-02T22:29:16Z
dc.date.available2020-09-02T22:29:16Z
dc.date.issued2018
dc.identifier10.1007/s12035-018-0934-y
dc.identifier.citation55, 9, 7285-7296
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6394
dc.descriptionImpaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (KOC), buttermilk fat globule membranes (BMFC), and a combination of both in aged rats. After 3 months of supplementation, although all groups of animals showed clear signs of peripheral insulin resistance, the combination of KOC and BMFC was able to improve peripheral insulin sensitivity. We also explored brain energy balance. Interestingly, the hippocampus of supplemented rats—mainly when supplemented with BMFC or the combination of KOC and BMFC—showed an increase in intracellular adenosine triphosphate (ATP) levels, whereas no difference was observed in the cerebral cortex. Moreover, we found a significant increase of brain-derived neurotrophic factor (BDNF) in the hippocampus of BMFC+KO animals. In summary, dietary supplementation with KOC and/or BMFC improves peripheral and central insulin resistance, suggesting that their administration could delay the onset of these phenomena. Moreover, n-3 fatty acids (FAs) ingested as phospholipids increase BDNF levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. Thus, dietary supplementation with n-3 FAs could protect local protein synthesis and energy balance within dendrites, favoring neuronal health and delaying cognitive decline associated to age-related disrepair. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectButtermilk
dc.subjectHippocampus
dc.subjectInsulin
dc.subjectKrill oil
dc.subjectPhospholipids
dc.subjectadenosine triphosphate
dc.subjectbrain derived neurotrophic factor
dc.subjectlinolenic acid
dc.subjectomega 3 fatty acid
dc.subjectphosphatidylethanolamine
dc.subjectphosphatidylinositol
dc.subjectphospholipid
dc.subjectbrain derived neurotrophic factor
dc.subjectfish oil
dc.subjectinsulin
dc.subjectphospholipid
dc.subjectaged
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain cortex
dc.subjectbuttermilk
dc.subjectbuttermilk fat globule membrane
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectenergy balance
dc.subjecthippocampus
dc.subjectinsulin resistance
dc.subjectinsulin signaling
dc.subjectkrill
dc.subjectlipid membrane
dc.subjectmale
dc.subjectmitochondrial biogenesis
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectprotein synthesis
dc.subjectrat
dc.subjectsynaptic transmission
dc.subjecttreatment duration
dc.subjectaging
dc.subjectanimal
dc.subjectchemistry
dc.subjectdiet
dc.subjectdrug effect
dc.subjectenergy metabolism
dc.subjecthippocampus
dc.subjectinsulin resistance
dc.subjectkrill
dc.subjectmetabolism
dc.subjectorganelle biogenesis
dc.subjectpathology
dc.subjectsignal transduction
dc.subjectsynapse
dc.subjectWistar rat
dc.subjectAging
dc.subjectAnimals
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectButtermilk
dc.subjectDiet
dc.subjectEnergy Metabolism
dc.subjectEuphausiacea
dc.subjectFish Oils
dc.subjectHippocampus
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectOrganelle Biogenesis
dc.subjectPhospholipids
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.subjectSynapses
dc.titleButtermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats
dc.typeArticle


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