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dc.contributor.authorTapia-Rojas C.
dc.contributor.authorCabezas-Opazo F.
dc.contributor.authorDeaton C.A.
dc.contributor.authorVergara E.H.
dc.contributor.authorJohnson G.V.W.
dc.contributor.authorQuintanilla R.A.
dc.date.accessioned2020-09-02T22:29:13Z
dc.date.available2020-09-02T22:29:13Z
dc.date.issued2019
dc.identifier10.1016/j.pneurobio.2018.12.005
dc.identifier.citation175, , 54-76
dc.identifier.issn03010082
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6371
dc.descriptionTau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend beyond its ability to modulate microtubule dynamics. Tau plays a role in mediating axonal transport, synaptic structure and function, and neuronal signaling pathways. Although tau plays important physiological roles in neurons, its involvement in neurodegenerative diseases, and most prominently in the pathogenesis of Alzheimer disease (AD), has directed the majority of tau studies. However, a thorough knowledge of the physiological functions of tau and its post-translational modifications under normal conditions are necessary to provide the foundation for understanding its role in pathological settings. In this review, we will focus on human tau, summarizing tau structure and organization, as well as its posttranslational modifications associated with physiological processes. We will highlight possible mechanisms involved in mediating the turnover of tau and finally discuss newly elucidated tau functions in a physiological context. © 2018 Elsevier Ltd
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectAxonal transport
dc.subjectDendrites
dc.subjectMicrotubules
dc.subjectPosttranslational modifications
dc.subjectTau
dc.subjecttau protein
dc.subjectubiquitin
dc.subjecttau protein
dc.subjectalternative RNA splicing
dc.subjectAlzheimer disease
dc.subjectautophagy
dc.subjectglycation
dc.subjecthuman
dc.subjectisomerization
dc.subjectmicrotubule
dc.subjectmitochondrial dynamics
dc.subjectnerve fiber transport
dc.subjectnitration
dc.subjectoligodendroglia
dc.subjectphysiological process
dc.subjectpriority journal
dc.subjectprotein cleavage
dc.subjectprotein degradation
dc.subjectprotein glycosylation
dc.subjectprotein methylation
dc.subjectprotein phosphorylation
dc.subjectprotein processing
dc.subjectReview
dc.subjectsignal transduction
dc.subjectstop codon
dc.subjectturnover rate
dc.subjectbrain
dc.subjectchemistry
dc.subjectphysiology
dc.subjectBrain
dc.subjectHumans
dc.subjecttau Proteins
dc.titleIt's all about tau
dc.typeReview


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