Universidad Autónoma de Chile
  • About
  • How to publish
  • Contact Us
    • Login

    Repositorio Académico

    Advanced search
    View Item 
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Synthesis of new hydrated geranylphenols and in vitro antifungal activity against botrytis cinerea

    Article
    View/Open
    item_2-s2.0-84971670332.pdf (3.466Kb)
    Date
    2016
    DOI
    10.3390/ijms17060840

    Metadata
    Show full item record
    Author
    Soto M.
    Espinoza L.
    Chávez M.I.
    Díaz K.
    Olea A.F.
    Taborga L.
    Abstract
    Geranylated hydroquinones and other geranylated compounds isolated from Aplydium species have shown interesting biological activities. This fact has prompted a number of studies where geranylated phenol derivatives have been synthesized in order to assay their bioactivities. In this work, we report the synthesis of a series of new hydrated geranylphenols using two different synthetic approaches and their inhibitory effects on the mycelial growth of Botrytis cinerea. Five new hydrated geranylphenols were obtained by direct coupling reaction between geraniol and phenol in dioxane/water and using BF3·Et2O as the catalyst or by the reaction of a geranylated phenol with BF3·Et2O. Two new geranylated quinones were also obtained. The synthesis and structural elucidation of all new compounds is presented. All hydrated geranylphenols efficiently inhibit the mycelial growth of B. cinerea. Their activity is higher than that observed for non-hydrated compounds. These results indicate that structural modification on the geranyl chain brings about an enhancement of the inhibition effect of geranylated phenol derivatives. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
    Collections
    • Artículos científicos

    Related items

    Showing items related by title, author, creator and subject.

    • Article

      Synthesis and in Vitro antifungal activity against Botrytis cinerea of geranylated phenols and their phenyl acetate derivatives (2020) 

      Chávez M.I.; Soto M.; Taborga L.; Díaz K.; Olea A.F.; Bay C.; Peña-Cortés H.; Espinoza L. (MDPI AG, 2015)
    • Article

      In vitro antifungal activity of new and known geranylated phenols against Phytophthora cinnamomi rands (2020) 

      Chavez M.I.; Soto M.; Cimino F.A.; Olea A.F.; Espinoza L.; Díaz K.; Taborga L. (MDPI AG, 2018)
    • Article

      Antifungal toxicity of linear geranylphenol. Influence of oxigenate substituents (2020) 

      Taborga L.; Sortino M.; Carrasco H.; Butassi E.; Zacchino S.; Espinoza L. (Elsevier Ltd, 2017)
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección

    Browse

    All contentCollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Academic Journals
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección