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dc.contributor.authorSaheb M.
dc.contributor.authorFereydouni N.
dc.contributor.authorNemati S.
dc.contributor.authorBarreto G.E.
dc.contributor.authorJohnston T.P.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:27:36Z
dc.date.available2020-09-02T22:27:36Z
dc.date.issued2019
dc.identifier10.1002/jcp.28024
dc.identifier.citation234, 8, 12325-12340
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6135
dc.descriptionEffective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin. © 2019 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectbioavailability
dc.subjectchitosan
dc.subjectcurcumin
dc.subjectdrug delivery
dc.subjectsolubility
dc.subjectchitosan
dc.subjectchitosan coated nanoparticle
dc.subjectchitosan nanoparticle
dc.subjectcurcumin
dc.subjectexcipient
dc.subjectmagnetic nanoparticle
dc.subjectnanocomposite
dc.subjectpolyelectrolyte
dc.subjectpolymer
dc.subjectturmeric
dc.subjectunclassified drug
dc.subjectchitosan
dc.subjectcurcumin
dc.subjectdrug carrier
dc.subjectnanoparticle
dc.subjectcross linking
dc.subjectdrug bioavailability
dc.subjectdrug delivery system
dc.subjectdrug solubility
dc.subjectendocytosis
dc.subjecthuman
dc.subjectnonhuman
dc.subjectpharmacodynamics
dc.subjectpriority journal
dc.subjectReview
dc.subjectanimal
dc.subjectbioavailability
dc.subjectchemistry
dc.subjectneoplasm
dc.subjectAnimals
dc.subjectBiological Availability
dc.subjectChitosan
dc.subjectCurcumin
dc.subjectDrug Carriers
dc.subjectHumans
dc.subjectNanoparticles
dc.subjectNeoplasms
dc.titleChitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects
dc.typeReview


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