Chitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects
MetadataShow full item record
Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin. © 2019 Wiley Periodicals, Inc.
Showing items related by title, author, creator and subject.
ReviewAskarizadeh A.; Barreto G.E.; Henney N.C.; Majeed M.; Sahebkar A. (Elsevier B.V., 2020)
Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies (2020) Motaharinia J.; Panahi Y.; Barreto G.E.; Beiraghdar F.; Sahebkar A. (Blackwell Publishing Inc., 2019)
Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets (2020) Ghanaatian N.; Lashgari N.-A.; Abdolghaffari A.H.; Rajaee S.M.; Panahi Y.; Barreto G.E.; Butler A.E.; Sahebkar A. (Wiley-Liss Inc., 2019)