Non-cytotoxic copper overload boosts mitochondrial energy metabolism to modulate cell proliferation and differentiation in the human erythroleukemic cell line K562
MetadataShow full item record
Copper is integral to the mitochondrial respiratory complex IV and contributes to proliferation and differentiation, metabolic reprogramming and mitochondrial function. The K562 cell line was exposed to a non-cytotoxic copper overload to evaluate mitochondrial dynamics, function and cell fate. This induced higher rates of mitochondrial turnover given by an increase in mitochondrial fusion and fission events and in the autophagic flux. The appearance of smaller and condensed mitochondria was also observed. Bioenergetics activity included more respiratory complexes, higher oxygen consumption rate, superoxide production and ATP synthesis, with no decrease in membrane potential. Increased cell proliferation and inhibited differentiation also occurred. Non-cytotoxic copper levels can modify mitochondrial metabolism and cell fate, which could be used in cancer biology and regenerative medicine. © 2016 Elsevier B.V. and Mitochondria Research Society.
Showing items related by title, author, creator and subject.
ReviewBusquets O.; Ettcheto M.; Cano A.; Manzine P.R.; Sánchez-Lopez E.; Espinosa-Jiménez T.; Verdaguer E.; Castro-Torres R.D.; Beas-Zarate C.; Sureda F.X.; ... (MDPI AG, 2020)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (2020) Tapia-Rojas C.; Carvajal F.J.; Mira R.G.; Arce C.; Lerma-Cabrera J.M.; Orellana J.A.; Cerpa W.; Quintanilla R.A. (Humana Press Inc., 2018)
Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood (2020) Tapia-Rojas C.; Torres A.K.; Quintanilla R.A. (Elsevier Ltd, 2019)