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dc.contributor.authorRetamal M.A.
dc.contributor.authorLeón-Paravic C.G.
dc.contributor.authorEzquer M.
dc.contributor.authorEzquer F.
dc.contributor.authorDel Rio R.
dc.contributor.authorPupo A.
dc.contributor.authorMartínez A.D.
dc.contributor.authorGonzález C.
dc.date.accessioned2020-09-02T22:26:55Z
dc.date.available2020-09-02T22:26:55Z
dc.date.issued2015
dc.identifier10.1002/iub.1388
dc.identifier.citation67, 6, 428-437
dc.identifier.issn15216543
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5979
dc.descriptionCarbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG. The other mechanism of action involves induction of protein carbonylation. CO is known to directly and indirectly modulate the function of ion channels at the plasma membrane, which in turn have important repercussions in the cellular behavior. One group of these channels is hemichannels, which are formed by proteins known as connexins (Cxs). Hemichannel allows not only the flow of ions through their pore but also the release of molecules such as ATP and glutamate. Therefore, their modulation not only impacts cellular function but also cellular communication, having the capability to affect tissular behavior. Here, we review the most recent results regarding the effect of CO on Cx hemichannels and their possible repercussions on pathologies. © 2015 IUBMB.
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectconnexins
dc.subjectgap junction channels
dc.subjectgaseous transmitters
dc.subjecthemichannels
dc.subjectpost-translational modification
dc.subjectredox potential
dc.subjectcarbon monoxide
dc.subjectgap junction protein
dc.subjection channel
dc.subjectnitric oxide
dc.subjectbrain ischemia
dc.subjectcell membrane
dc.subjectchemistry
dc.subjectgap junction
dc.subjecthuman
dc.subjectmetabolism
dc.subjectoxidation reduction reaction
dc.subjectBrain Ischemia
dc.subjectCarbon Monoxide
dc.subjectCell Membrane
dc.subjectConnexins
dc.subjectGap Junctions
dc.subjectHumans
dc.subjectIon Channels
dc.subjectNitric Oxide
dc.subjectOxidation-Reduction
dc.titleCarbon monoxide: A new player in the redox regulation of connexin hemichannels
dc.typeReview


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