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dc.contributor.authorPutta S.
dc.contributor.authorPeluso I.
dc.contributor.authorYarla N.S.
dc.contributor.authorKilari E.K.
dc.contributor.authorBishayee A.
dc.contributor.authorLu D.-Y.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.contributor.authorScotti L.
dc.contributor.authorScotti M.T.
dc.contributor.authorSingla R.K.
dc.contributor.authorAlexiou T.
dc.contributor.authorAtanasov A.G.
dc.contributor.authorTarasov V.V.
dc.contributor.authorBramhachari P.V.
dc.contributor.authorImandi S.B.
dc.contributor.authorChintala M.
dc.contributor.authorSharma B.
dc.contributor.authorReale M.
dc.contributor.authorFilosa R.
dc.contributor.authorAliev G.
dc.contributor.authorKamal M.A.
dc.date.accessioned2020-09-02T22:26:00Z
dc.date.available2020-09-02T22:26:00Z
dc.date.issued2017
dc.identifier10.2174/1381612823666170823103830
dc.identifier.citation23, 30, 4475-4483
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5861
dc.descriptionAndropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years. Older diabetics tend to have both impaired insulin release as well as insulin resistance. There is growing evidence indicating the pathophysiological connections among the mechanisms of oxidative damage by disruption of the oxidative balance, increased levels of enzymatic glycation products in testicular region and glucose transporters, obesity and proinflammatory cytokines in male infertile patients with diabetes. Epidemiological studies suggest that many clinical findings in diabetics are linked to low testosterone levels. This article reviews pathophysiological mechanisms, observational studies, and clinical implications of testosterone therapy in type 2 diabetes mellitus. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAndropause
dc.subjectDiabetes mellitus
dc.subjectHypogonadism
dc.subjectInsulin
dc.subjectProinflammatory cytokines
dc.subjectTestosterone
dc.subjectadvanced glycation end product
dc.subjectcytokine
dc.subjectsildenafil
dc.subjecttadalafil
dc.subjecttestosterone
dc.subjecttestosterone undecanoate
dc.subjectaging
dc.subjectandrogen deficiency
dc.subjectandrogen therapy
dc.subjectandropause
dc.subjectdisease association
dc.subjectejaculation disorder
dc.subjecterectile dysfunction
dc.subjecthuman
dc.subjecthypogonadism
dc.subjectinflammation
dc.subjectinsulin resistance
dc.subjectlibido disorder
dc.subjectmale infertility
dc.subjectmale sexual dysfunction
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectobesity
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectReview
dc.subjecttestosterone blood level
dc.titleDiabetes mellitus and male aging: Pharmacotherapeutics and clinical implications
dc.typeReview


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