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dc.contributor.authorOlloquequi J.
dc.contributor.authorJaime S.
dc.contributor.authorParra V.
dc.contributor.authorCornejo-Córdova E.
dc.contributor.authorValdivia G.
dc.contributor.authorAgustí
dc.contributor.authorSilva O. R.
dc.date.accessioned2020-09-02T22:24:48Z
dc.date.available2020-09-02T22:24:48Z
dc.date.issued2018
dc.identifier10.1186/s12931-018-0718-y
dc.identifier.citation19, 1, -
dc.identifier.issn14659921
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5653
dc.descriptionBackground: Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is characterized by an abnormal inflammatory response, both in the pulmonary and systemic compartments. The differential effects of TS, BS or their combined exposure have not been well characterized yet. This study sought to compare the lung function characteristics and systemic inflammatory response in COPD patients exposed to TS, BS or their combination. Methods: Sociodemographic, clinical and lung functional parameters were compared across 49 COPD patients with a history of smoking and no BS exposure (TS COPD), 31 never-smoker COPD patients with BS exposure (BS COPD), 46 COPD patients with a combined exposure (TS + BS COPD) and 52 healthy controls (HC) who have never been exposed neither to TS or BS. Blood cell counts, C-reactive protein (CRP), fibrinogen and immunoglobulin E (IgE) levels were quantified in all four groups. Results: TS + BS COPD patients exhibited significantly lower oxygen saturation than the rest of groups (p < 0.01). Spirometry and diffusing capacity were significantly higher in BS than in TS or TS + BS patients. CRP levels were significantly higher in TS COPD patients than in BS COPD group (p < 0.05), whereas fibrinogen was raised in COPD patients with a history of smoking (TS and TS + BS) when compared to control subjects (p < 0.01). Finally, COPD patients with BS exposure (BS and BS + TS groups) showed higher IgE levels than TS and HC (p < 0.05). Conclusions: There are significant physiological and inflammatory differences between COPD patients with TS, BS and TS + BS exposures. The latter had worse blood oxygenation, whereas the raised levels of IgE in BS exposed patients suggests a differential Th2 systemic inflammatory pattern triggered by this pollutant. © 2018 The Author(s).
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.subjectBiomass smoke
dc.subjectCOPD
dc.subjectImmunoglobulin E
dc.subjectIndoor pollution
dc.subjectOxygen saturation
dc.subjectSystemic inflammation
dc.subjectC reactive protein
dc.subjectfibrinogen
dc.subjectimmunoglobulin E
dc.subjectautacoid
dc.subjectaged
dc.subjectArticle
dc.subjectbiomass
dc.subjectbiomass smoke
dc.subjectblood cell count
dc.subjectchronic obstructive lung disease
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdemography
dc.subjectenvironmental exposure
dc.subjectfemale
dc.subjectfunctional assessment
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinflammatory disease
dc.subjectlung diffusion capacity
dc.subjectmale
dc.subjectmedical history
dc.subjectoxygen saturation
dc.subjectrespiratory tract parameters
dc.subjectsmoke
dc.subjectsmoking
dc.subjectspirometry
dc.subjectsystemic disease
dc.subjectblood
dc.subjectchronic obstructive lung disease
dc.subjectenvironmental exposure
dc.subjectforced expiratory volume
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectprocedures
dc.subjectsmoke
dc.subjectsmoking
dc.subjecttrends
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomass
dc.subjectEnvironmental Exposure
dc.subjectFemale
dc.subjectForced Expiratory Volume
dc.subjectHumans
dc.subjectInflammation Mediators
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectSmoke
dc.subjectSpirometry
dc.subjectTobacco Smoking
dc.titleComparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both
dc.typeArticle


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