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dc.contributor.authorMuresanu D.F.
dc.contributor.authorSharma A.
dc.contributor.authorLafuente J.V.
dc.contributor.authorNozari A.
dc.contributor.authorPatnaik R.
dc.contributor.authorOzkizilcik A.
dc.contributor.authorTian Z.R.
dc.contributor.authorMössier H.
dc.contributor.authorSharma H.S.
dc.date.accessioned2020-09-02T22:24:07Z
dc.date.available2020-09-02T22:24:07Z
dc.date.issued2017
dc.identifier.citation3, , 79-82
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5504
dc.descriptionMilitary personnel are quite vulnerable to heat stroke in hot environment leading to mental dysfunction. Due to severe work stress and irregular food habits they could develop hypertension and diabetes. In this innovation, we demonstrate that a combination of heat stress with diabetes (DB) and hypertension (HY) adversely affect brain function resulting in mental abnormalities and exacerbation of brain pathology. Our observations in a rat model show that a combination of diabetes (DB) and hypertension (HY) exacerbates blood-brain barrier (BBB) breakdown, edema formation and brain injury. It appears that excessive upregulation of nitric oxide synthase (NOS) and heme oxygenease-2 (HO-2) following heat stroke in DBHY rats resulting in excessive brain pathology. In such situation, TiO2 nanowired delivery of cerebrolysin has superior effects in reducing BBB breakdown, brain edema, NOS and HO-2 expression and brain pathology in DBHY rats after heat stroke as compared to cerebrolysin alone, not reported earlier.
dc.language.isoen
dc.publisherTechConnect
dc.sourceCase F.Laudon M.Case F.Romanowicz B.
dc.subjectBlood-brain barrier
dc.subjectBrain edema
dc.subjectBrain pathology
dc.subjectDiabetes
dc.subjectHeat stroke
dc.subjectHeme oxygenase
dc.subjectHypertension
dc.subjectNitric oxide
dc.subjectTiO2 nanowired cerebrolysin
dc.subjectMedical problems
dc.subjectNitric oxide
dc.subjectPathology
dc.subjectPorphyrins
dc.subjectRats
dc.subjectBlood-brain barrier
dc.subjectBrain edema
dc.subjectBrain pathologies
dc.subjectHeat stroke
dc.subjectHeme oxygenases
dc.subjectHypertension
dc.subjectTiO2 nanowired cerebrolysin
dc.subjectBlood
dc.titleNeuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke
dc.typeConference Paper


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