Neuroprotection in hypoxic-ischemic brain injury targeting glial cells
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Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action. © 2017 Bentham Science Publishers.
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Short SurveyHerrera M.I.; Kölliker-Frers R.; Barreto G.; Blanco E.; Capani F. (Frontiers Media S.A., 2016)