Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

Article
View/Open
Date
2014
DOI
10.3390/molecules191118993

Metadata
Show full item record
Author
Montenegro I.
Tomasoni G.
Bosio C.
Quiñones N.
Madrid A.
Carrasco H.
Olea A.
Martinez R.
Cuellar M.
Villena J.
Abstract
Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.
Collections