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dc.contributor.authorMontalbano G.
dc.contributor.authorMania M.
dc.contributor.authorAbbate F.
dc.contributor.authorNavarra M.
dc.contributor.authorGuerrera M.C.
dc.contributor.authorLaura R.
dc.contributor.authorVega J.A.
dc.contributor.authorLevanti M.
dc.contributor.authorGermanà A.
dc.date.accessioned2020-09-02T22:23:32Z
dc.date.available2020-09-02T22:23:32Z
dc.date.issued2018
dc.identifier10.1007/s12020-018-1653-x
dc.identifier.citation62, 2, 381-393
dc.identifier.issn1355008X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5389
dc.descriptionPurpose: Overweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. In teleost, it can control energy balance by activating or inhibiting appetite-related peptides. The study aims at testing effects of melatonin administration to control-fed and overfed zebrafish, in terms of expression levels of orexigenic (Ghrelin, orexin, NPY) and anorexigenic (leptin, POMC) genes expression and morphometry of visceral and subcutaneous fat depots. Methods: Adult male zebrafish (n = 56) were divided into four dietary groups: control, overfed, control + melatonin, overfed + melatonin. The treatment lasted 5 weeks and BMI levels of every fish were measured each week. After this period fishes were sacrificed; morphological and morphometric studies have been carried out on histological sections of adipose tissue and adipocytes. Moreover, whole zebrafish brain and intestine were used for qRT-PCR. Results: Our results demonstrate that melatonin supplementation may have an effect in mobilizing fat stores, in increasing basal metabolism and thus in preventing further excess fat accumulation. Melatonin stimulates the anorexigenic and inhibit the orexigenic signals. Conclusions: It seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAdipose tissue
dc.subjectDiet-induced obesity
dc.subjectMelatonin
dc.subjectZebrafish
dc.subjectanorexigenic agent
dc.subjectappetite stimulant
dc.subjectghrelin
dc.subjectleptin
dc.subjectmelatonin
dc.subjectnuclear factor Y
dc.subjectorexin
dc.subjectmelatonin
dc.subjectmessenger RNA
dc.subjectneuropeptide Y
dc.subjectorexin
dc.subjectproopiomelanocortin
dc.subjectadipocyte
dc.subjectadipose tissue
dc.subjectadult
dc.subjectagriculture
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbasal metabolic rate
dc.subjectbody mass
dc.subjectbody weight gain
dc.subjectbody weight loss
dc.subjectbrain
dc.subjectcontrolled study
dc.subjectdiet induced obesity
dc.subjectdiet supplementation
dc.subjectdrug effect
dc.subjectfood intake
dc.subjectgene expression
dc.subjectintestine
dc.subjectintra-abdominal fat
dc.subjectlipid storage
dc.subjectmale
dc.subjectmorphology
dc.subjectmorphometry
dc.subjectnonhuman
dc.subjectplasticity
dc.subjectpriority journal
dc.subjectreal time polymerase chain reaction
dc.subjectsubcutaneous fat
dc.subjecttissue section
dc.subjecttreatment duration
dc.subjectzebra fish
dc.subjectadipose tissue
dc.subjectanimal
dc.subjectappetite
dc.subjectbrain chemistry
dc.subjectcell count
dc.subjectcell size
dc.subjectcytology
dc.subjectdiet
dc.subjectdisease model
dc.subjectgene expression
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectobesity
dc.subjectAdipocytes
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectAppetite
dc.subjectBody Mass Index
dc.subjectBrain Chemistry
dc.subjectCell Count
dc.subjectCell Size
dc.subjectDiet
dc.subjectDisease Models, Animal
dc.subjectGene Expression
dc.subjectMale
dc.subjectMelatonin
dc.subjectNeuropeptide Y
dc.subjectObesity
dc.subjectOrexins
dc.subjectPro-Opiomelanocortin
dc.subjectRNA, Messenger
dc.subjectZebrafish
dc.titleMelatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish
dc.typeArticle


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