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dc.contributor.authorMarcus N.J.
dc.contributor.authorPügge C.
dc.contributor.authorMediratta J.
dc.contributor.authorSchiller A.M.
dc.contributor.authordel Rio R.
dc.contributor.authorZucker I.H.
dc.contributor.authorSchultz H.D.
dc.date.accessioned2020-09-02T22:22:21Z
dc.date.available2020-09-02T22:22:21Z
dc.date.issued2015
dc.identifier10.1152/ajpheart.00268.2015
dc.identifier.citation309, 2, H259-H266
dc.identifier.issn03636135
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5203
dc.descriptionIn chronic heart failure (CHF), carotid body chemoreceptor (CBC) activity is increased and contributes to increased tonic and hypoxia-evoked elevation in renal sympathetic nerve activity (RSNA). Elevated RSNA and reduced renal perfusion may contribute to development of the cardio-renal syndrome in CHF. Exercise training (EXT) has been shown to abrogate CBC-mediated increases in RSNA in experimental heart failure, however, the effect of EXT on CBC control of renal blood flow (RBF) is undetermined. We hypothesized that CBCs contribute to tonic reductions in RBF in CHF, that stimulation of the CBC with hypoxia would result in exaggerated reductions in RBF, and that these responses would be attenuated with EXT. RBF was measured in CHF-sedentary (SED), CHF-EXT, CHF-carotid body denervation (CBD), and CHF-renal denervation (RDNX) groups. We measured RBF at rest and in response to hypoxia (FIO<inf>2</inf> 10%). All animals exhibited similar reductions in ejection fraction and fractional shortening as well as increases in ventricular systolic and diastolic volumes. Resting RBF was lower in CHF-SED (29 ± 2 ml/min) than in CHF-EXT animals (46 ± 2 ml/min, P ± 0.05) or in CHF-CBD animals (42 ± 6 ml/min, P < 0.05). In CHF-SED, RBF decreased during hypoxia, and this was prevented in CHF-EXT animals. Both CBD and RDNX abolished the RBF response to hypoxia in CHF. Mean arterial pressure increased in response to hypoxia in CHF-SED, but was prevented by EXT, CBD, and RDNX. EXT is effective in attenuating chemoreflex-mediated tonic and hypoxia-evoked reductions in RBF in CHF. © 2015 the American Physiological Society.
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.subjectCarotid chemoreflex
dc.subjectExercise training
dc.subjectHeart failure
dc.subjectRenal blood flow
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcarotid body chemoreceptor
dc.subjectchemoreceptor reflex
dc.subjectcongestive heart failure
dc.subjectcontrolled study
dc.subjectdenervation
dc.subjectechocardiography
dc.subjectexercise
dc.subjectheart ejection fraction
dc.subjectheart ventricle contraction
dc.subjectheart ventricle filling
dc.subjecthypoxia
dc.subjectkidney blood flow
dc.subjectkidney denervation
dc.subjectkidney perfusion
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsympathetic nerve
dc.subjectanimal
dc.subjectanoxia
dc.subjectarterial pressure
dc.subjectcarotid body
dc.subjectdisease model
dc.subjectheart contraction
dc.subjectheart failure
dc.subjectheart left ventricle function
dc.subjectheart stroke volume
dc.subjectinnervation
dc.subjectkidney
dc.subjectkidney circulation
dc.subjectkinesiotherapy
dc.subjectpathophysiology
dc.subjectrabbit
dc.subjectreflex
dc.subjecttime
dc.subjectvascularization
dc.subjectAnimals
dc.subjectAnoxia
dc.subjectArterial Pressure
dc.subjectCarotid Body
dc.subjectDenervation
dc.subjectDisease Models, Animal
dc.subjectExercise Therapy
dc.subjectHeart Failure
dc.subjectKidney
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectRabbits
dc.subjectReflex
dc.subjectRenal Circulation
dc.subjectStroke Volume
dc.subjectTime Factors
dc.subjectVentricular Function, Left
dc.titleExercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure
dc.typeArticle


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