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dc.contributor.authorMarcus N.J.
dc.contributor.authorDel Rio R.
dc.contributor.authorSchultz H.D.
dc.date.accessioned2020-09-02T22:22:21Z
dc.date.available2020-09-02T22:22:21Z
dc.date.issued2014
dc.identifier10.3389/fphys.2014.00438
dc.identifier.citation5, Nov, -
dc.identifier.issn1664042X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5202
dc.descriptionOscillatory breathing (OB) patterns are observed in pre-term infants, patients with cardio-renal impairment, and in otherwise healthy humans exposed to high altitude. Enhanced carotid body (CB) chemoreflex sensitivity is common to all of these populations and is thought to contribute to these abnormal patterns by destabilizing the respiratory control system. OB patterns in chronic heart failure (CHF) patients are associated with greater levels of tonic and chemoreflex-evoked sympathetic nerve activity (SNA), which is associated with greater morbidity and poor prognosis. Enhanced chemoreflex drive may contribute to tonic elevations in SNA by strengthening the relationship between respiratory and sympathetic neural outflow. Elimination of CB afferents in experimental models of CHF has been shown to reduce OB, respiratory-sympathetic coupling, and renal SNA, and to improve autonomic balance in the heart. The CB chemoreceptors may play an important role in progression of CHF by contributing to respiratory instability and OB, which in turn further exacerbates tonic and chemoreflex-evoked increases in SNA to the heart and kidney. © 2014 Marcus, Del Rio and Schultz.
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectCardiorenal syndrome
dc.subjectCarotid body chemoreceptors
dc.subjectCheyne-Stokes respiration
dc.subjectHeart failure
dc.subjectSympathetic nervous system
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectautonomic nervous system
dc.subjectbreathing disorder
dc.subjectcardiorenal syndrome
dc.subjectcarotid body chemoreceptor
dc.subjectchemoreceptor reflex
dc.subjectCheyne Stokes breathing
dc.subjectdisease association
dc.subjectheart failure
dc.subjectheart muscle oxygen consumption
dc.subjecthuman
dc.subjectnonhuman
dc.subjectrenin angiotensin aldosterone system
dc.subjectrespiratory sympathetic coupling
dc.subjectrespiratory tract parameters
dc.subjectsodium retention
dc.subjectsympathetic nerve activity
dc.subjecttidal volume
dc.subjectvascular resistance
dc.subjectwater retention
dc.titleCentral role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure
dc.typeArticle


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