Inflammatory damage and karyometric changes in cardiac tissue from mice experimentally infected with Trypanosoma cruzi [Daño Inflamatorio y Cambios Cariométricos en Tejido Cardiaco de Ratones Experimentalmente Infectados con Trypanosoma cruzi]
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In this study were evaluated the karyometric alterations caused by strains Munantá and Tulahuén and clon Dm28c of Trypanosoma cruzi in cardiac tissue in ACA mice infected experimentally with 2000 blood tripomastigotes of the parasite and the relationship with inflammatory damage, number of pseudocysts and correlation with parasitemia levels and mortality. Results showed a significant increase in the nuclear size in cardiac tissue of infected mice compared with control mice. Infected mice with Tulahuén strain or clon Dm28c showed a 5-day blood prepatency, with a maximum parasitemia levels of 16.23 x 105 ± 2.21 x 105 parasites/ml on day 11 post infection - p.i. -(Tulahuén strain) and 20.10 x 105 ± 2.25 x 105 parasites/ml on day 9 p.i. (clon Dm28c) while mice infected with Munantá strain showed a 7-day prepatency and a significantly higher maximum parasitemia level (42.57 x 105 ± 2.10 x 105 parasites/ml; p<0.001) at 17 days p.i. Mice infected with Munantá showed a 75% survival beyond six months p.i. as compared to 100% mortality in mice infected with Tulahuén strain and clon Dm28c at 21 and 23 days p.i. respectively. The histopathological analysis suggested a correlation at least at day 19 p.i. between intracellular parasites (pseudocysts), the magnitude of mononuclear inflammatory infiltrate, the severity of damage in cardiac tissue and mortality of infected mice with Tulahuén strain and clon Dm28c despite the low level of parasitemia, so not always exists a correlation between the levels of parasitemia and resistance or susceptibility to infection with T. cruzi. Finally, the kariometric study indicates that there is no correlation between an increased nuclear size in cardiac tissue and virulence or biological characteristics of the isolated parasite.
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