Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model
MetadataShow full item record
De Souza W.
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model. © 2017 Mariá Inés Herrera et al.
Showing items related by title, author, creator and subject.
ArticleHerrera, María Inés; Kobiec, Tamara; Kölliker-Frers, Rodolfo Alberto; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2020-09-23)Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It ...
A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple Sclerosis (2020) Herrera M.I.; Kölliker-Frers R.A.; Otero-Losada M.; Perez Lloret S.; Filippo M.; Tau J.; Capani F.; Villa A.M. (Frontiers Media S.A., 2019)
Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease (2021) Kölliker Frers, Rodolfo Alberto; Udovin, Lucas Daniel; Otero-Losada, Matilde; Kobiec, Tamara; Herrera, María Inés; Palacios, Jorge; Razzitte, Gabriela; Capani, Francisco (Hindawi Limited, 2021)The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or ...