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RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration

dc.contributor.authorGąsiorowski K.
dc.contributor.authorBrokos B.
dc.contributor.authorEcheverria V.
dc.contributor.authorBarreto G.E.
dc.contributor.authorLeszek J.
dc.date.accessioned2020-09-02T22:19:59Z
dc.date.available2020-09-02T22:19:59Z
dc.date.issued2018
dc.identifier10.1007/s12035-017-0419-4
dc.identifier.citation55, 2, 1463-1476
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4838
dc.descriptionChronic inflammatory reactions are consistenly present in neurodegeneration of Alzheimer type and are considered important factors that accelerate progression of the disease. Receptors of innate immunity participate in triggering and driving inflammatory reactions. For example, Toll-like receptors (TLRs) and receptor for advanced glycation end product (RAGE), major receptors of innate immunity, play a central role in perpetuation of inflammation. RAGE activation should be perceived as a primary mechanism which determines self-perpetuated chronic inflammation, and RAGE cooperation with TLRs amplifies inflammatory signaling. In this review, we highlight and discuss that RAGE-TLR crosstalk emerges as an important driving force of chronic inflammation in Alzheimer’s disease. © 2017, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectChronic inflammation
dc.subjectNeurodegeneration
dc.subjectRage
dc.subjectSelf-perpetuated stimulation
dc.subjectTLR
dc.subjectadvanced glycation end product receptor
dc.subjectfree radical
dc.subjecttoll like receptor
dc.subjectadvanced glycation end product receptor
dc.subjecttoll like receptor
dc.subjectAlzheimer disease
dc.subjectbrain level
dc.subjectchronic inflammation
dc.subjectchronic stress
dc.subjectdisease course
dc.subjectgene amplification
dc.subjecthuman
dc.subjectimmunoreactivity
dc.subjectinnate immunity
dc.subjectnerve degeneration
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein protein interaction
dc.subjectprotein structure
dc.subjectreceptor cross-talk
dc.subjectReview
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectdegenerative disease
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectnerve degeneration
dc.subjectphysiology
dc.subjectAnimals
dc.subjectHumans
dc.subjectInflammation
dc.subjectNerve Degeneration
dc.subjectNeurodegenerative Diseases
dc.subjectReceptor for Advanced Glycation End Products
dc.subjectSignal Transduction
dc.subjectToll-Like Receptors
dc.titleRAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
dc.typeReview


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