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dc.contributor.authorGómez-Santos C.
dc.contributor.authorSaura C.B.
dc.contributor.authorLucas J.A.R.
dc.contributor.authorCastell P.
dc.contributor.authorMadrid J.A.
dc.contributor.authorGaraulet M.
dc.date.accessioned2020-09-02T22:19:58Z
dc.date.available2020-09-02T22:19:58Z
dc.date.issued2016
dc.identifier10.1097/GME.0000000000000612
dc.identifier.citation23, 6, 682-690
dc.identifier.issn10723714
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4830
dc.descriptionObjective: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metabolic syndrome (MetS) components. Methods: A total of 177 women were studied (127 premenopausal, 50 postmenopausal). Sixty percent of the total population was overweight/obese, with no significant differences between premenopausal (60%) and postmenopausal women (62%) (P = 0.865). Wrist temperature (WT) and rest-activity cycles were measured during 8 consecutive days, and sleep and food diaries collected. MetS characteristics and daily patterns of saliva cortisol were analyzed. Sleep characteristics were assessed with domiciliary polysomnography. Results: Postmenopausal women showed a less robust rhythm in WT with lower amplitude (°C) (0.8 ± 0.4 vs 0.9 ± 0.5) (P < 0.05) and lower mean temperature values at the midpoint of sleep than premenopausal women. Postmenopausal women were also more morning-type than premenopausal women, showing a phase advance of approximately 1 hour in WT and rest-activity rhythms, and more morning-type habits (earlier sleep onset/offset and breakfast intake) (P < 0.05). Postmenopausal women showed higher levels of activity in the morning and lower in the evening compared with premenopausal women (P < 0.05). Daily variability in cortisol was significantly reduced in postmenopausal women compared with premenopausal women (P < 0.05). Postmenopausal women had increased frequency of sleep-related breathing abnormalities (P < 0.0001). In the women studied, abdominal fat and MetS were associated with an increase in circadian alterations (high fragmentation and low amplitude of the rhythm) (P < 0.05). Conclusions: Postmenopausal women exhibit loss of circadian robustness and an increase in sleep abnormalities compared with premenopausal women. © 2016 by The North American Menopause Society.
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.subjectCircadian
dc.subjectCortisol
dc.subjectMenopause
dc.subjectObesity
dc.subjectPolysomnography
dc.subjectTemperature
dc.subjecthydrocortisone
dc.subjecthydrocortisone
dc.subjectabdominal fat
dc.subjectabdominal obesity
dc.subjectadult
dc.subjectArticle
dc.subjectcircadian rhythm
dc.subjectcircadian rhythm sleep disorder
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmetabolic syndrome X
dc.subjectoxygen saturation
dc.subjectphysical parameters
dc.subjectpolysomnography
dc.subjectpostmenopause
dc.subjectrespiratory disturbance index
dc.subjectrest activity cycle
dc.subjectsleep quality
dc.subjecttemperature
dc.subjectwrist temperature
dc.subjectabdominal obesity
dc.subjectanalysis
dc.subjectbody composition
dc.subjectchemistry
dc.subjectcircadian rhythm
dc.subjectdiet
dc.subjectglucose blood level
dc.subjectmetabolic syndrome X
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpostmenopause
dc.subjectpremenopause
dc.subjectsaliva
dc.subjectsleep
dc.subjectsleep disorder
dc.subjectSpain
dc.subjectAbdominal Fat
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectBody Composition
dc.subjectCircadian Rhythm
dc.subjectDiet
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectMetabolic Syndrome
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectObesity, Abdominal
dc.subjectOverweight
dc.subjectPostmenopause
dc.subjectPremenopause
dc.subjectSaliva
dc.subjectSleep
dc.subjectSleep Wake Disorders
dc.subjectSpain
dc.titleMenopause status is associated with circadian- and sleep-related alterations
dc.typeArticle


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