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dc.contributor.authorGuzmán M.A.
dc.contributor.authorOlguín M.A.
dc.contributor.authorGronhert M.O.
dc.date.accessioned2020-09-02T22:19:50Z
dc.date.available2020-09-02T22:19:50Z
dc.date.issued2015
dc.identifier10.3305/nh.2015.31.3.7955
dc.identifier.citation31, 3, 1129-1133
dc.identifier.issn02121611
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4771
dc.descriptionObjective: To investigate the relationship between oxidative stress and biochemical parameters and the expression of TXNIP, IL-6, IL-1β and TNF-α in peripheral mononuclear cells (PMCs) from type-2 diabetic patients. Methods: We studied 60 males: 20 normal-weight type- 2 diabetic patients (NW), 20 obese diabetic patients (OB) and 20 controls (C). Biochemical and oxidative stress parameters were evaluated. PMCs were isolated and total RNA was extracted in order to determine the expression of TXNIP, IL-6, IL-1β and TNF-α by qRT-PCR. Results: OB had higher weight, BMI and abdominal circumference (One way ANOVA, p<0.0001). NW had higher fasting glycemia (One way ANOVA, p=0.0034) however OB had higher HbA1c (One way ANOVA, p<0.0001). OB also had higher hsCRP (One way ANOVA, p=0.0158). TBARS and AGES were elevated in both NW and OB (One way ANOVA, p<0.0001 and p=0.0008, respectively). Compared to OB and C participants, the expression of TXNIP was significantly higher in NW (Kruskal Wallis, p=0.0074); IL-1β, IL-6 and TNF-α transcripts were higher in NW and OB (Kruskal Wallis, p<0.0001, for all). In NW patients, the expression of TXNIP was positively correlated with fasting glycemia and AGES and negatively correlated with HOMA-β (r=0.72; r=0.59; r=-0.44, respectively, for all p<0.05), in OB there was correlation only with 8-Isoprostanes (r=0.42, p=0.046). Conclusions: Our results suggest that fasting glycemic control, independent of adiposity and nutritional status, represents a risk factor for β-cell dysfunction, increases oxidative stress markers and it is related with an elevation of TXNIP expression. © 2015, Grupo Aula Medica S.A. All rights reserved.
dc.language.isoen
dc.publisherGrupo Aula Medica S.A.
dc.subjectAGEs
dc.subjectGlycemic control
dc.subjectInflammation
dc.subjectTXNIP
dc.subjectβ-cell function
dc.subjectCallithrix
dc.subject8-epi-prostaglandin F2alpha
dc.subjectadvanced glycation end product
dc.subjectantidiabetic agent
dc.subjectcarrier protein
dc.subjectglucose blood level
dc.subjectglycosylated hemoglobin
dc.subjectIL6 protein, human
dc.subjectinsulin
dc.subjectinterleukin 1beta
dc.subjectinterleukin 6
dc.subjectlipid
dc.subjectprostaglandin F2 alpha
dc.subjectthiobarbituric acid reactive substance
dc.subjecttumor necrosis factor alpha
dc.subjectTXNIP protein, human
dc.subjectadult
dc.subjectanalogs and derivatives
dc.subjectanalysis
dc.subjectanthropometry
dc.subjectblood
dc.subjectbody mass
dc.subjectbody weight
dc.subjectcomplication
dc.subjectDiabetes Mellitus, Type 2
dc.subjectfemale
dc.subjectgenetics
dc.subjectglucose blood level
dc.subjecthuman
dc.subjectinflammation
dc.subjectmale
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectoxidative stress
dc.subjectAdult
dc.subjectAnthropometry
dc.subjectBlood Glucose
dc.subjectBody Mass Index
dc.subjectBody Weight
dc.subjectCarrier Proteins
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDinoprost
dc.subjectFemale
dc.subjectGlycosylation End Products, Advanced
dc.subjectHemoglobin A, Glycosylated
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.subjectInflammation
dc.subjectInsulin
dc.subjectInterleukin-1beta
dc.subjectInterleukin-6
dc.subjectLipids
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOverweight
dc.subjectOxidative Stress
dc.subjectThiobarbituric Acid Reactive Substances
dc.subjectTumor Necrosis Factor-alpha
dc.titleGlycemic control and oxidative stress markers and their relationship with the thioredoxin interacting protein (Txnip) gene in type 2 diabetic patients [Control Glicémico Y Marcadores De Estrés Oxidativo Y Su Relación Con El Gen De La Proteína Interactuante Con La Tioredoxina (Txnip) En Sujetos Diabéticos Tipo 2]
dc.typeArticle


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