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Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice
dc.contributor.author | Grizzell J.A. | |
dc.contributor.author | Mullins M. | |
dc.contributor.author | Iarkov A. | |
dc.contributor.author | Rohani A. | |
dc.contributor.author | Charry L.C. | |
dc.contributor.author | Echeverria V. | |
dc.date.accessioned | 2020-09-02T22:19:28Z | |
dc.date.available | 2020-09-02T22:19:28Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1037/bne0000021 | |
dc.identifier.citation | 128, 6, 713-721 | |
dc.identifier.issn | 07357044 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/4753 | |
dc.description | Cotinine, the predominant metabolite of nicotine, appears to act as an antidepressant. We have previously shown that cotinine reduced immobile postures in Porsolt's forced swim (FS) and tail suspension tests while preserving the synaptic density in the hippocampus as well as prefrontal and entorhinal cortices of mice subjected to chronic restraint stress. In this study, we investigated the effect of daily oral cotinine (5 mg/kg) on depressive-like behavior induced by repeated, FS stress for 6 consecutive days in adult, male C57BL/6J mice. The results support our previous report that cotinine administration reduces depressive-like behavior in mice subjected or not to high salience stress. In addition, cotinine enhanced the expression of the vascular endothelial growth factor (VEGF) in the hippocampus of mice subjected to repetitive FS stress. Altogether, the results suggest that cotinine may be an effective antidepressant positively influencing mood through a mechanism involving the preservation of brain homeostasis and the expression of critical growth factors such as VEGF. | |
dc.language.iso | en | |
dc.publisher | American Psychological Association Inc. | |
dc.subject | Depressive disorders | |
dc.subject | Forced swim | |
dc.subject | Neurogenesis | |
dc.subject | Vascular endothelial growth factor | |
dc.subject | cotinine | |
dc.subject | vasculotropin | |
dc.subject | antidepressant agent | |
dc.subject | bungarotoxin receptor | |
dc.subject | cotinine | |
dc.subject | cyclic AMP responsive element binding protein binding protein | |
dc.subject | Dlgh4 protein, mouse | |
dc.subject | guanylate kinase | |
dc.subject | membrane protein | |
dc.subject | messenger RNA | |
dc.subject | tubulin | |
dc.subject | vasculotropin A | |
dc.subject | adult | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | animal tissue | |
dc.subject | antidepressant activity | |
dc.subject | Article | |
dc.subject | brain metabolism | |
dc.subject | controlled study | |
dc.subject | depression | |
dc.subject | down regulation | |
dc.subject | drug efficacy | |
dc.subject | drug mechanism | |
dc.subject | forced swim test | |
dc.subject | hippocampus | |
dc.subject | male | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | protein analysis | |
dc.subject | protein expression | |
dc.subject | animal | |
dc.subject | C57BL mouse | |
dc.subject | complication | |
dc.subject | depression | |
dc.subject | disease model | |
dc.subject | drug effects | |
dc.subject | genetics | |
dc.subject | mental stress | |
dc.subject | metabolism | |
dc.subject | psychology | |
dc.subject | swimming | |
dc.subject | time | |
dc.subject | alpha7 Nicotinic Acetylcholine Receptor | |
dc.subject | Animals | |
dc.subject | Antidepressive Agents | |
dc.subject | Cotinine | |
dc.subject | CREB-Binding Protein | |
dc.subject | Depression | |
dc.subject | Disease Models, Animal | |
dc.subject | Down-Regulation | |
dc.subject | Guanylate Kinase | |
dc.subject | Hippocampus | |
dc.subject | Male | |
dc.subject | Membrane Proteins | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | RNA, Messenger | |
dc.subject | Stress, Psychological | |
dc.subject | Swimming | |
dc.subject | Time Factors | |
dc.subject | Tubulin | |
dc.subject | Vascular Endothelial Growth Factor A | |
dc.title | Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice | |
dc.type | Article |