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dc.contributor.authorGiordano A.
dc.contributor.authorFuentes-Barros G.
dc.contributor.authorCastro-Saavedra S.
dc.contributor.authorGonzález-Cooper A.
dc.contributor.authorSuárez-Rozas C.
dc.contributor.authorSalas-Norambuena J.
dc.contributor.authorAcevedo-Fuentes W.
dc.contributor.authorLeyton F.
dc.contributor.authorTirapegui C.
dc.contributor.authorEcheverría J.
dc.contributor.authorClaros S.
dc.contributor.authorCassels B.K.
dc.date.accessioned2020-09-02T22:19:16Z
dc.date.available2020-09-02T22:19:16Z
dc.date.issued2019
dc.identifier10.1177/1934578X19856258
dc.identifier.citation14, 6, -
dc.identifier.issn1934578X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4676
dc.descriptionCryptocarya alba is an important tree species in the Chilean sclerophyllous forest. Its leaves and bark are used in traditional medicine to treat liver diseases and rheumatism. Analyses of the essential oil (EO) show serious discrepancies, and information on other constituents is limited. The aerial biomass of individual trees from 3 wild populations, some old trees, and farmed saplings were analyzed (n = 132). The EO profiles were studied by gas chromatography/mass spectrometry (GC/MS). The alkaloidal and polyphenol compositions were determined by ultra-high-performance liquid chromatography (UHPLC)/ MS-MS. The total polyphenol content, the total flavonoid content, and the antioxidant capacity (diphenylpicrylhydrazyl, azi-nobisethylbenzothiazolinesulfonic acid, and ferric reducing antioxidant power: DPPH, ABTS, and FRAP respectively) were determined by standard methods. Significant differences were found at the individual and population levels in the contents of polyphenols, total flavonoids, antioxidant capacity, and specific alkaloids for leaves, bark, and wood. Farmed saplings grown under less light showed higher concentrations of higenamine, N-methylcoclaurine, N-methyllaurotetanine, and isocorydine, while those receiving more light were richer in laurolitsine, boldine, coclaurine, catechin, quercetin, epicatechin, quercitrin, and procyanidins. Important variations were found according to the season, age of the tree and of the leaves. The EO composition also varied considerably. These results support the idea that the natural variability of medicinal species is an important subject for study. © The Author(s) 2019
dc.language.isoen
dc.publisherNatural Product Incorporation
dc.subjectAlkaloids
dc.subjectCryptocarya alba
dc.subjectGC-MS
dc.subjectPolyphenols
dc.subjectUHPLC-MS/MS
dc.subjectalkaloid derivative
dc.subjectantiinfective agent
dc.subjectantiinflammatory agent
dc.subjectantioxidant
dc.subjectboldine
dc.subjectcamphene
dc.subjectchlorogenic acid
dc.subjectcineole
dc.subjectcoclaurine
dc.subjectCryptocarya alba extract
dc.subjectepicatechin
dc.subjectessential oil
dc.subjecthigenamine
dc.subjectisocorydine
dc.subjectlaurolitsine
dc.subjectlimonene
dc.subjectmyrcene
dc.subjectn methylcoclaurine
dc.subjectn methyllaurotetanine
dc.subjectpinene
dc.subjectplant extract
dc.subjectplant medicinal product
dc.subjectpolyphenol derivative
dc.subjectprocyanidin
dc.subjectquercetin
dc.subjectquercitrin
dc.subjectunclassified drug
dc.subjectABTS radical scavenging assay
dc.subjectaerial plant part
dc.subjectaged tree
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbark
dc.subjectbiomass
dc.subjectChilean
dc.subjectDPPH radical scavenging assay
dc.subjectferric reducing antioxidant power assay
dc.subjectforest
dc.subjectliquid chromatography-mass spectrometry
dc.subjectliver disease
dc.subjectmass fragmentography
dc.subjectmedicinal plant
dc.subjectmedicinal species
dc.subjectmetabolite
dc.subjectplant leaf
dc.subjectrheumatic disease
dc.subjectsapling
dc.subjectseason
dc.subjectstandard
dc.subjectultra performance liquid chromatography
dc.subjectwood
dc.titleVariation of secondary metabolites in the aerial biomass of cryptocarya alba
dc.typeArticle


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