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dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorGarcía-Mesa Y.
dc.contributor.authorFeito J.
dc.contributor.authorGarcía B.
dc.contributor.authorQuiros L.M.
dc.contributor.authorMartín-Biedma B.
dc.contributor.authorCobo T.
dc.contributor.authorVega J.A.
dc.contributor.authorGarcía-Suárez O.
dc.date.accessioned2020-09-02T22:18:52Z
dc.date.available2020-09-02T22:18:52Z
dc.date.issued2019
dc.identifier10.1016/j.aanat.2019.02.007
dc.identifier.citation224, , 62-72
dc.identifier.issn09409602
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4644
dc.descriptionPacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Here we used immunohistochemistry to investigate the distribution of class I (biglycan, decorin, asporin, ECM2 and ECMX) and class II (fibromodulin, lumican, prolargin, keratocan and osteoadherin) small leucine-rich proteoglycans in human cutaneous Pacinian corpuscles. The distribution of these compounds was: the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. Asporin, prolargin and keratocan were undetectable. These results complement our knowledge about the distribution of small leucine-rich proteoglycans in human Pacinian corpuscles, and help to understand the composition of the extracellular matrix in these sensory formations. © 2019 Elsevier GmbH
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectExtracellular matrix
dc.subjectHuman
dc.subjectPacinian corpuscles
dc.subjectSmall leucine-rich proteoglycans
dc.subjectasporin
dc.subjectbiglycan
dc.subjectdecorin
dc.subjectfibromodulin
dc.subjectkeratocan
dc.subjectlumican
dc.subjectosteoadherin
dc.subjectprolargin
dc.subjectsmall leucine rich proteoglycan
dc.subjectsmall leucine rich proteoglycan class I
dc.subjectsmall leucine rich proteoglycan class II
dc.subjectunclassified drug
dc.subjectbiglycan
dc.subjectCD34 antigen
dc.subjectdecorin
dc.subjectfibromodulin
dc.subjectosteoadherin
dc.subjectprotein S 100
dc.subjectproteoglycan
dc.subjectscleroprotein
dc.subjectvimentin
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectchild
dc.subjectcontrolled study
dc.subjectextracellular matrix
dc.subjecthuman
dc.subjecthuman experiment
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectnormal human
dc.subjectPacini corpuscle
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectsignal transduction
dc.subjectanatomy and histology
dc.subjectanimal
dc.subjectchemistry
dc.subjectclassification
dc.subjectEquidae
dc.subjectfinger
dc.subjectfluorescent antibody technique
dc.subjectgoat
dc.subjectLeporidae
dc.subjectmiddle aged
dc.subjectmouse
dc.subjectPacini corpuscle
dc.subjectskin
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnimals
dc.subjectAntigens, CD34
dc.subjectBiglycan
dc.subjectChild
dc.subjectDecorin
dc.subjectEquidae
dc.subjectExtracellular Matrix Proteins
dc.subjectFibromodulin
dc.subjectFingers
dc.subjectFluorescent Antibody Technique
dc.subjectGoats
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMice
dc.subjectMiddle Aged
dc.subjectPacinian Corpuscles
dc.subjectProteoglycans
dc.subjectRabbits
dc.subjectS100 Proteins
dc.subjectSkin
dc.subjectVimentin
dc.subjectYoung Adult
dc.titleClass I and Class II small leucine-rich proteoglycans in human cutaneous pacinian corpuscles
dc.typeArticle


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