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dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorGarcía-Mesa Y.
dc.contributor.authorCárcaba L.
dc.contributor.authorFeito J.
dc.contributor.authorTorres-Parejo I.
dc.contributor.authorMartín-Biedma B.
dc.contributor.authorCobo J.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:18:51Z
dc.date.available2020-09-02T22:18:51Z
dc.date.issued2019
dc.identifier10.1111/joa.12983
dc.identifier.citation234, 6, 839-852
dc.identifier.issn00218782
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4643
dc.descriptionDecline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse the age-dependent changes in Meissner's and Pacinian corpuscles as well as in Merkel cell-neurite complexes. Moreover, variations in the neurotrophic TrkB-BDNF system and the mechanoprotein Piezo2 (involved in maintenance of cutaneous mechanoreceptors and light touch, respectively) were evaluated. The number of Meissner's corpuscles and Merkel cells decreased progressively with ageing. Meissner's corpuscles were smaller, rounded in morphology and located deeper in the dermis, and signs of corpuscular denervation were found in the oldest subjects. Pacinian corpuscles generally showed no relevant age-related alterations. Reduced expression of Piezo2 in the axon of Meissner's corpuscles and in Merkel cells was observed in old subjects, as well was a decline in the BDNF-TrkB neurotrophic system. This study demonstrates that cutaneous Meissner's corpuscles and Merkel cell-neurite complexes (and less evidently Pacinian corpuscles) undergo morphological and size changes during the ageing process, as well as a reduction in terms of density. Furthermore, the mechanoprotein Piezo2 and the neurotrophic TrkB-BDNF system are reduced in aged corpuscles. Taken together, these alterations might explain part of the impairment of the somatosensory system associated with ageing. © 2019 Anatomical Society
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectageing
dc.subjectBDNF-TrkB system
dc.subjectglabrous skin innervation
dc.subjecthuman
dc.subjectPiezo2
dc.subjectsensory corpuscles
dc.subjectbrain derived neurotrophic factor
dc.subjectbrain derived neurotrophic factor receptor
dc.subjection channel
dc.subjectPiezo2 protein
dc.subjectunclassified drug
dc.subjectadult
dc.subjectaged
dc.subjectaging
dc.subjectArticle
dc.subjectaxon
dc.subjectcell density
dc.subjectcell size
dc.subjectcell structure
dc.subjectcontrolled study
dc.subjectdenervation
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmale
dc.subjectmechanoreceptor
dc.subjectMeissner corpuscle
dc.subjectMerkel cell
dc.subjectPacini corpuscle
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectskin receptor
dc.subjectsomatosensory disorder
dc.subjectsomatosensory system
dc.subjecttouch
dc.subjectvery elderly
dc.titleAgeing of the somatosensory system at the periphery: age-related changes in cutaneous mechanoreceptors
dc.typeArticle


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