Interindividual variation in cardiorespiratory fitness: A candidate gene study in han Chinese people
MetadataShow full item record
Del Coso J.
Cardiorespiratory fitness, as assessed through peak oxygen uptake (VO2peak), is a powerful health indicator. We aimed to evaluate the influence of several candidate causal genetic variants on VO2peak level in untrained Han Chinese people. A total of 1009 participants (566 women; age [mean ± SD] 40 ± 14 years, VO2peak 29.9 ± 7.1 mL/kg/min) performed a maximal incremental cycling test for VO2peak determination. Genomic DNA was extracted from peripheral whole blood, and genotyping analysis was performed on 125 gene variants. Using age, sex, and body mass as covariates, and setting a stringent threshold p-value of 0.0004, only one single nucleotide polymorphism (SNP), located in the gene encoding angiotensin-converting enzyme (rs4295), was associated with VO2peak (β = 0.87; p < 2.9 × 10−4). Stepwise multiple regression analysis identified a panel of three SNPs (rs4295 = 1.1%, angiotensin II receptor type 1 rs275652 = 0.6%, and myostatin rs7570532 = 0.5%) that together accounted for 2.2% (p = 0.0007) of the interindividual variance in VO2peak. Participants carrying six ‘favorable’ alleles had a higher VO2peak (32.3 ± 8.1 mL/kg/min) than those carrying only one favorable allele (24.6 ± 5.2 mL/kg/min, p < 0.0001). In summary, VO2peak at the pre-trained state is partly influenced by several polymorphic variations in candidate genes, but they represent a minor portion of the variance. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Showing items related by title, author, creator and subject.
Renin-angiotensin system as a potential target for new therapeutic approaches in Parkinson’s disease (2020) Perez-Lloret S.; Otero-Losada M.; Toblli J.E.; Capani F. (Taylor and Francis Ltd, 2017)
ArticleGómez G.I.; Velarde V. (MDPI AG, 2018)
Th17 response and autophagy - Main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: New factors involved in inflammatory bowel disease susceptibility [Respuesta Th17 y autofagia: Principales vías implicadas en enfermedad inflamatoria intestinal por los estudios de asociación de genoma completo: Nuevos factores implicados en la susceptibilidad a enfermedad inflamatoria intestinal] (2020) Díaz-Peña R.; Valdés E.; Cofré C.; Castro-Santos P. (ARAN Ediciones S.A., 2015)