Histological changes implicated in metastasis [Cambios histológicos implicados en metástasis]
MetadataShow full item record
The process of malignancy emergence is associated with the acquisition of the capacity to invade other tissues. Several different biological processes have been described as involved in this process. Specifically, epithelial mesenchymal transition (EMT), a mechanism associated with embryogenesis and wound repair but also with mobility acquisition, is one of the concerned processes. In EMT an epithelial cell loses its epithelial characteristics, its junctions with neighbor cells and with the basal lamina and acquires mobility and mesenchymal characteristics. Also, factors of the tumor microenvironment have been described as involved. Tumor presence triggers a response in the surrounding tissue known as reactive stromal. It shows particular characteristics similar to those found in wound healing stroma: an increase of the fibroblast number and enhancing of the capillary density. The notable difference is the chronicity in the tumoral process. Of a high relevance seems to be the role of activated macrophages with a characteristic phenotype. Finally, cancer associated fibroblasts (CAF) are a type of cells found in tumors, developed from local tissue or possibly from bone marrow. CAF characteristically show a distinct morphology and secrete a high number of metalloproteases allowing tumoral cells advance through the tissue. Additionally, CAF have a direct effect on the survival of the epithelial cells. The three processes are interrelated and metastasis is probably caused by the effect of all of them and probably by other additional factors. © 2014, Universidad de la Frontera. All rights reserved.
Showing items related by title, author, creator and subject.
Th17 response and autophagy - Main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: New factors involved in inflammatory bowel disease susceptibility [Respuesta Th17 y autofagia: Principales vías implicadas en enfermedad inflamatoria intestinal por los estudios de asociación de genoma completo: Nuevos factores implicados en la susceptibilidad a enfermedad inflamatoria intestinal] (2020) Díaz-Peña R.; Valdés E.; Cofré C.; Castro-Santos P. (ARAN Ediciones S.A., 2015)
Genetic study confirms association of HLA-DPA1*01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations (2020) Díaz-Peña R.; Castro-Santos P.; Aransay A.M.; Brüges-Armas J.; Pimentel-Santos F.M.; López-Larrea C. (2013)
Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications (2020) Díaz-Peña R.; de los Santos M.J.; Lucia A.; Castro-Santos P. (Springer New York LLC, 2019)