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dc.contributor.authorDib T.
dc.contributor.authorMartínez-Pinto J.
dc.contributor.authorReyes-Parada M.
dc.contributor.authorTorres G.E.
dc.contributor.authorSotomayor-Zárate R.
dc.date.accessioned2020-09-02T22:16:39Z
dc.date.available2020-09-02T22:16:39Z
dc.date.issued2018
dc.identifier10.1016/j.bbr.2017.12.001
dc.identifier.citation346, , 80-85
dc.identifier.issn01664328
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4275
dc.descriptionResearch in programming is focused on the study of stimuli that alters sensitive periods in development, such as prenatal and neonatal stages, that can produce long-term deleterious effects. These effects can occur in various organs or tissues such as the brain, affecting brain circuits and related behaviors. Our laboratory has demonstrated that neonatal programming with sex hormones affects the mesocorticolimbic circuitry, increasing the synthesis and release of dopamine (DA) in striatum and nucleus accumbens (NAcc). However, the behavioral response to psychostimulant drugs such as methylphenidate and the possible mechanism(s) involved have not been studied in adult rats exposed to sex hormones during the first hours of life. Thus, the aim of this study was to examine the locomotor activity induced by methylphenidate (5 mg/kg i.p.) and the expression of the DA transporter (DAT) in NAcc of adult rats exposed to a single dose of testosterone propionate (TP: 1 mg/50 μL s.c.) or estradiol valerate (EV: 0.1 mg/50 μL s.c.) at postnatal day 1. Our results demonstrated that adult female rats treated with TP have a lower methylphenidate-induced locomotor activity compared to control and EV-treated adult female rats. This reduction in locomotor activity is related with a lower NAcc DAT expression. However, neither methylphenidate-induced locomotor activity nor NAcc DAT expression was affected in EV or TP-treated adult male rats. Our results suggest that early exposure to sex hormones affects long-term dopaminergic brain areas involved in the response to psychostimulants, which could be a vulnerability factor to favor the escalating doses of drugs of abuse. © 2017 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectDAT
dc.subjectLocomotor activity
dc.subjectMethylphenidate
dc.subjectProgramming
dc.subjectTestosterone
dc.subjectdopamine transporter
dc.subjectestradiol valerate
dc.subjectmethylphenidate
dc.subjecttestosterone propionate
dc.subjectcentral nervous system agents
dc.subjectdopamine transporter
dc.subjectestradiol
dc.subjectmethylphenidate
dc.subjecttestosterone propionate
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbehavior
dc.subjectcognition
dc.subjectcontrolled study
dc.subjectcorpus striatum
dc.subjectdopamine release
dc.subjectfemale
dc.subjecthormone action
dc.subjectlocomotion
dc.subjectmale
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectperinatal period
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrat
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectdrug effect
dc.subjectgrowth, development and aging
dc.subjectlocomotion
dc.subjectmetabolism
dc.subjectmotor activity
dc.subjectnucleus accumbens
dc.subjectphysiology
dc.subjectrandomization
dc.subjectsexual characteristics
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectCentral Nervous System Agents
dc.subjectDopamine Plasma Membrane Transport Proteins
dc.subjectEstradiol
dc.subjectFemale
dc.subjectLocomotion
dc.subjectMale
dc.subjectMethylphenidate
dc.subjectMotor Activity
dc.subjectNucleus Accumbens
dc.subjectRandom Allocation
dc.subjectRats, Sprague-Dawley
dc.subjectSex Characteristics
dc.subjectTestosterone Propionate
dc.titleNeonatal programming with testosterone propionate reduces dopamine transporter expression in nucleus accumbens and methylphenidate-induced locomotor activity in adult female rats
dc.typeArticle


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