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dc.contributor.authorChávez M.I.
dc.contributor.authorSoto M.
dc.contributor.authorTaborga L.
dc.contributor.authorDíaz K.
dc.contributor.authorOlea A.F.
dc.contributor.authorBay C.
dc.contributor.authorPeña-Cortés H.
dc.contributor.authorEspinoza L.
dc.date.accessioned2020-09-02T22:14:52Z
dc.date.available2020-09-02T22:14:52Z
dc.date.issued2015
dc.identifier10.3390/ijms160819130
dc.identifier.citation16, 8, 19130-19152
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4021
dc.descriptionThe inhibitory effects on the mycelial growth of plant pathogen Botritys cinérea have been evaluated for a series of geranylphenols substituted with one, two and three methoxy groups in the aromatic ring. The results show that the antifungal activity depends on the structure of the geranylphenols, increasing from 40% to 90% by increasing the number of methoxy groups. On the other hand, the acetylation of the -OH group induces a change of activity that depends on the number of methoxy groups. The biological activity of digeranyl derivatives is lower than that exhibited by the respective monogeranyl compound. All tested geranylphenols have been synthesized by direct coupling of geraniol and the respective phenol. The effect of solvent on yields and product distribution is discussed. For monomethoxyphenols the reaction gives better yields when acetonitrile is used as a solvent and AgNO3 is used as a secondary catalyst. However, for di- and trimethoxyphenols the reaction proceeds only in dioxane. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntifungal activity
dc.subjectBotrytis cinerea
dc.subjectGeranylphenols
dc.subjectGreen chemistry
dc.subjectSynthesis
dc.subject2 (3,7 dimethylocta 2,6 dienyl) 4 methoxyphenol
dc.subject2 (3,7 dimethylocta 2,6 dienyl) 4 methoxyphenyl acetate
dc.subject2 (3,7 dimethylocta 2,6 dienyl) 4,5 dimethoxyphenol
dc.subject2 (3,7 dimethylocta 2,6 dienyl) 4,5 dimethoxyphenyl acetate
dc.subject2 (3,7 dimethylocta 2,6 dienyl) 6 methoxyphenyl acetate
dc.subject3 (3,7 dimethylocta 2,6 dien 1 yl) 2,4,6 trimethoxyphenol
dc.subject3 (3,7 dimethylocta 2,6 dienyl) 2,4,6 trimethoxyphenyl acetate
dc.subject3,5 bis(3,7 dimethylocta 2,6 dien 1 yl) 2,4,6 trimethoxyphenol
dc.subject5 (3,7 dimethylocta 2,6 dienyl) 2,4 dimethoxyphenol
dc.subjectcaptan
dc.subjectgeraniol
dc.subjectguaiacol
dc.subjectphenylacetic acid derivative
dc.subjectphloroglucinol
dc.subjectunclassified drug
dc.subjectacetic acid derivative
dc.subjectfungicide
dc.subjectgeraniol
dc.subjectphenol derivative
dc.subjectphenyl acetate
dc.subjectterpene
dc.subjectacetylation
dc.subjectantifungal activity
dc.subjectArticle
dc.subjectBotrytis cinerea
dc.subjectcatalyst
dc.subjectcontrolled study
dc.subjectgrowth inhibition
dc.subjectmycelial growth
dc.subjectnonhuman
dc.subjectproton nuclear magnetic resonance
dc.subjectthin layer chromatography
dc.subjectBotrytis
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectgreen chemistry
dc.subjectgrowth, development and aging
dc.subjectmycelium
dc.subjectsynthesis
dc.subjectBotryotinia fuckeliana
dc.subjectAcetates
dc.subjectBotrytis
dc.subjectFungicides, Industrial
dc.subjectGreen Chemistry Technology
dc.subjectMycelium
dc.subjectPhenols
dc.subjectTerpenes
dc.titleSynthesis and in Vitro antifungal activity against Botrytis cinerea of geranylated phenols and their phenyl acetate derivatives
dc.typeArticle


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