Genetics of rheumatoid arthritis: A new boost is needed in Latin American populations
MetadataShow full item record
Rheumatoid arthritis (RA) is an autoimmune inflammatory rheumatic disease which affects several organs and tissue, predominantly the synovial joints. Like many other autoimmune diseases, RA is a complex disease, where genetic variants, environmental factors and random events interact to trigger pathological pathways. Genetic implication in RA is evident, and recent advances have expanded our knowledge about the genetic factors that contribute to RA. An exponential increment in the number of genes associated with the disease has been described, mainly through gene wide screen studies (GWAS) involving international consortia with large patient cohorts. However, there are a few studies on Latin American populations. This article describes what is known about the RA genetics, the future that is emerging, and how this will develop a more personalized approach for the treatment of the disease. Latin American RA patients cannot be excluded from this final aim, and a higher collaboration with the international consortia may be needed for a better knowledge of the genetic profile of patients from this origin. © 2015 Elsevier Editora Ltda. All rights reserved.
Showing items related by title, author, creator and subject.
Amerindian ancestry influences genetic susceptibility to chronic obstructive pulmonary disease (2020) Díaz-Peña R.; Boekstegers F.; Silva R.S.; Jaime S.; Hosgood H.D.; III; Miravitlles M.; Agustí À.; Bermejo J.L.; Olloquequi J. (MDPI AG, 2020)
Th17 response and autophagy - Main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: New factors involved in inflammatory bowel disease susceptibility [Respuesta Th17 y autofagia: Principales vías implicadas en enfermedad inflamatoria intestinal por los estudios de asociación de genoma completo: Nuevos factores implicados en la susceptibilidad a enfermedad inflamatoria intestinal] (2020) Díaz-Peña R.; Valdés E.; Cofré C.; Castro-Santos P. (ARAN Ediciones S.A., 2015)
Genomics, proteomics and metabolomics: Their emerging roles in the discovery and validation of rheumatoid arthritis biomarkers (2020) Castro-Santos P.; Laborde C.M.; Díaz-Peña R. (Clinical and Experimental Rheumatology S.A.S., 2015)