Show simple item record

dc.contributor.authorCarvajal F.
dc.contributor.authorLerma-Cabrera J.M.
dc.contributor.authorAlcaraz-Iborra M.
dc.contributor.authorNavarro M.
dc.contributor.authorThiele T.E.
dc.contributor.authorCubero I.
dc.date.accessioned2020-09-02T22:14:16Z
dc.date.available2020-09-02T22:14:16Z
dc.date.issued2017
dc.identifier10.3389/fnbeh.2017.00167
dc.identifier.citation11, , -
dc.identifier.issn16625153
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3939
dc.descriptionThe melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol palatability in adult rats. Ethanol exposure during adolescence causes long-lasting changes in neural pathways critically involved in neurobehavioral responses to ethanol. In this regard, binge-like ethanol exposure during adolescence reduces basal alpha-melanocyte-stimulating hormone (α-MSH) and alters the levels of agouti-related peptide (AgRP) in hypothalamic and limbic areas. Given the protective role of MC against excessive ethanol consumption, disturbances in the MC system induced by binge-like ethanol exposure during adolescence might contribute to excessive ethanol consumption during adulthood. In the present study, we evaluated whether binge-like ethanol exposure during adolescence leads to elevated ethanol intake and/or eating disturbance during adulthood. Toward that aim, Sprague-Dawley rats were treated with ethanol (3 g/kg i.p.; BEP group) or saline (SP group) for 14 days (PND 25 to PND 38). On PND73, all the groups were given access to 20% ethanol on an intermittent schedule. Our results showed that adult rats given intermittent access (IAE) to 20% ethanol achieved high spontaneous ethanol intake that was not significantly enhanced by binge-like ethanol pretreatment during adolescence. However, BEP group exhibited an increase in food intake without a parallel increase in body weight (BW) relative to SP group suggesting caloric efficiency disturbance. Additionally, we evaluated whether binge-like ethanol exposure during adolescence alters the expected reduction in feeding and ethanol consumption following NAc shell administration of a selective MC4-R agonist in adult rats showing high rates of ethanol consumption. For that, animals in each pretreatment condition (SP and BEP) were divided into three subgroups and given bilateral NAc infusions of the selective MC4-R agonist cyclo(NH-CH2 -CH2 -CO-His-D-Phe-Arg-Trp-Glu)-NH2 (0, 0.75 or 1.5 µg). Results revealed that MC4-R stimulation within the NAc reduced feeding and ethanol intake in high ethanol-drinking adult rats, regardless of previous binge-like ethanol exposure during adolescence, which adds new evidence regarding the dual ability of MC compounds to control excessive ethanol and food intake. © 2017 Carvajal, Lerma-Cabrera, Alcaraz-Iborra, Navarro, Thiele and Cubero.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAdolescence
dc.subjectBinge-like ethanol exposure
dc.subjectIntermittent-access ethanol paradigm
dc.subjectMC4-R
dc.subjectMelanocortin
dc.subjectNucleus accumbens
dc.subjectalcohol
dc.subjectmelanocortin 4 receptor
dc.subjectmelanocortin receptor agonist
dc.subjectadolescent
dc.subjectadult
dc.subjectalcohol consumption
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectblood level
dc.subjectbody weight gain
dc.subjectcaloric intake
dc.subjectcontrolled study
dc.subjecteating disorder
dc.subjectexposure
dc.subjectfood intake
dc.subjectmale
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectnucleus accumbens shell
dc.subjectprotein function
dc.subjectrat
dc.titleNucleus accumbens MC4-R stimulation reduces food and ethanol intake in adult rats regardless of binge-like ethanol exposure during adolescence
dc.typeArticle


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record