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dc.contributor.authorCafferata E.A.
dc.contributor.authorJerez A.
dc.contributor.authorVernal R.
dc.contributor.authorMonasterio G.
dc.contributor.authorPandis N.
dc.contributor.authorFaggion C.M.
dc.contributor.authorJr.
dc.date.accessioned2020-09-02T22:13:46Z
dc.date.available2020-09-02T22:13:46Z
dc.date.issued2019
dc.identifier10.1111/jre.12629
dc.identifier.citation54, 3, 207-217
dc.identifier.issn00223484
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3864
dc.descriptionThis systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high-ranked scientific journals in “periodontics/immunology” and the references listed in the included studies. There were no language, year or publication status restrictions. Two independent reviewers selected and extracted the data, and Cohen's Kappa coefficient was calculated to determine the inter-examiner agreement. The Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) tool was used to assess the RoB. A total of 21 of the 425 studies obtained from the database search were included. Treg function was mainly described in Porphyromonas gingivalis-induced periodontitis (57.1%) in mice (76.2%), where Treg suppression was strongly related to disease progression and Treg induction was strongly related to immuno-inflammatory response reduction. Of those 21 studies, eight included eight animal experiments using three distinct therapeutic approaches, including: P. gingivalis-driven immunization (n = 3), retinoic acid inoculation (n = 2) and anti-inflammatory molecules in polymeric carriers (n = 3), which could modulate the Treg activity through cytokine production (interleukin-10 and transforming growth factor-β1), CC-chemokine- and CC-chemokine receptor-mediated chemoattraction (CCL22 and CCR4) or Th17-associated receptor activator of nuclear factor κB ligand (RANKL) downregulation. However, the studies with animal experiments did not specify the randomization sequences and housing conditions that were used, and therefore, 42.11% of the entries were rated as unclear RoB. Distinct therapeutic strategies involving Tregs could potentially suppress the immuno-inflammatory response and restore alveolar bone homeostasis during periodontitis. Nevertheless, important methodological variability, poor reporting of treatment effect estimates and unclear RoB suggest using caution when assessing the results of these studies. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.language.isoen
dc.publisherBlackwell Munksgaard
dc.subjectanimal experimentation
dc.subjectperiodontitis
dc.subjectregulatory T lymphocytes
dc.subjectreview
dc.subjectbeta chemokine
dc.subjectcytokine
dc.subjectosteoclast differentiation factor
dc.subjectanimal
dc.subjectBacteroidaceae infection
dc.subjectbibliographic database
dc.subjecthuman
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmouse
dc.subjectperiodontitis
dc.subjectPorphyromonas gingivalis
dc.subjectregulatory T lymphocyte
dc.subjectAnimals
dc.subjectBacteroidaceae Infections
dc.subjectChemokines, CC
dc.subjectCytokines
dc.subjectDatabases, Bibliographic
dc.subjectHumans
dc.subjectMice
dc.subjectPeriodontitis
dc.subjectPorphyromonas gingivalis
dc.subjectRANK Ligand
dc.subjectT-Lymphocytes, Regulatory
dc.titleThe therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review
dc.typeReview


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