New ABCC2 RS3740066 and RS2273697 polymorphisms identified in a healthy colombian cohort
MetadataShow full item record
Multidrug resistance-associated proteins (MRP) 1 and 2 belong to the ABC (ATP-Binding Cassette) transporters. These transport proteins are involved in the removal of various drugs and xenobiotics, as well as in multiple physiological, pathological, and pharmacological processes. There is a strong correlation between different polymorphisms and their clinical implication in resistance to antiepileptic drugs, anticancer, and anti-infective agents. In our study, we evaluated exon regions of MRP1 (ABCC1)/MRP2 (ABCC2) in a Colombian cohort of healthy subjects to determine single nucleotide polymorphisms (SNPs) and to determine the allelic and genomic frequency. Results showed there are SNPs in our population that have been previously reported for both MRP1/ABCC1 (rs200647436, rs200624910, rs150214567) and MRP2/ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Additionally, 13 new SNPs were identified. Evidence also shows a significant clinical correlation for polymorphisms rs3740066 and rs2273697 in the transport of multiple drugs, which suggests a genetic variability in regards to that reported in other populations. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Showing items related by title, author, creator and subject.
The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population (2020) Fernández-Vega B.; García M.; Olivares L.; Álvarez L.; González-Fernández A.; Artime E.; Fernández-Vega Cueto A.; Cobo T.; Coca-Prados M.; Vega J.A.; ... (Blackwell Publishing Ltd, 2020)
Association study of high-frequency variants of MTHFR gene with retinal vein occlusion in a Spanish population (2020) Fernández-Vega B.; Álvarez L.; García M.; Artime E.; González Fernández A.; Fernández-Vega C.; Nicieza J.; Vega J.A.; González-Iglesias H. (Taylor and Francis Ltd, 2019)
rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts (2020) Fuku N.; Díaz-Peña R.; Arai Y.; Abe Y.; Pareja-Galeano H.; Sanchis-Gomar F.; Santos-Lozano A.; Zempo H.; Naito H.; Murakami H.; ... (Elsevier Ireland Ltd, 2016)