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    Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats

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    item_2-s2.0-84930632014.pdf (3.538Kb)
    Date
    2015
    DOI
    10.1016/j.bbr.2015.05.009

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    Author
    Burgos H.
    Cofré C.
    Hernández A.
    Sáez-Briones P.
    Agurto R.
    Castillo A.
    Morales B.
    Zeise M.L.
    Abstract
    Methylphenidate (MPH) is widely used as a "nootropic" agent and in the treatment of disorders of attention, and has been shown to modulate synaptic plasticity in vitro. Here we present in vivo evidence that this MPH-induced metaplasticity can last long after the end of treatment. MPH (0, 0.2, 1 and 5. mg/kg) was administered daily to male rats from postnatal day 42 for 15 days. The animals were tested daily in a radial maze. Long-term potentiation (LTP), a marker of neural plasticity, was induced in vivo in the prefrontal cortex after 2-3. h, 15-18 days or 5 months without treatment. The behavioral performance of the 1. mg/kg group improved, while that of animals that had received 5. mg/kg deteriorated. In the 1 and 5. mg/kg groups LTP induced 2-3. h after the last MPH treatment was twice as large as in the controls. Further, 15-18 days after the last MPH administration, in groups receiving 1 and 5. mg/kg, LTP was about fourfold higher than in controls. However, 5 months later, LTP in the 1. mg/kg group was similar to controls and in the 5. mg/kg group LTP could not be induced at all. No significant changes of LTP were seen in the low-dose group of animals (0.2. mg/kg). Thus, firstly, doses of MPH that improve learning coincide approximately with those that augment LTP. Secondly, MPH-induced increases in LTP can last for several weeks, but these may disappear over longer periods or deteriorate at high doses. © 2015 Elsevier B.V.
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    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección