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dc.contributor.authorBrzecka A.
dc.contributor.authorLeszek J.
dc.contributor.authorAshraf G.M.
dc.contributor.authorEjma M.
dc.contributor.authorÁvila-Rodriguez M.F.
dc.contributor.authorYarla N.S.
dc.contributor.authorTarasov V.V.
dc.contributor.authorChubarev V.N.
dc.contributor.authorSamsonova A.N.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:13:34Z
dc.date.available2020-09-02T22:13:34Z
dc.date.issued2018
dc.identifier10.3389/fnins.2018.00330
dc.identifier.citation12, MAY, -
dc.identifier.issn16624548
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3798
dc.descriptionSleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-β. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD. © 2018 Brzecka, Leszek, Ashraf, Ejma, ávila-Rodriguez, Yarla, Tarasov, Chubarev, Samsonova, Barreto and Aliev.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAD
dc.subjectDiagnosis
dc.subjectDisturbance
dc.subjectSleep disorders
dc.subjectSleep-rhythm
dc.subjectamyloid beta protein
dc.subjectactimetry
dc.subjectAlzheimer disease
dc.subjectbrain interstitial fluid
dc.subjectcircadian rhythm sleep disorder
dc.subjectclinical feature
dc.subjectcognitive defect
dc.subjectdegenerative disease
dc.subjectdisease association
dc.subjecthuman
dc.subjectneurophysiology
dc.subjectpolysomnography
dc.subjectprognosis
dc.subjectquestionnaire
dc.subjectREM sleep
dc.subjectrestless legs syndrome
dc.subjectShort Survey
dc.subjectsleep deprivation
dc.subjectsleep disorder
dc.subjectsleep disordered breathing
dc.subjectsleep pattern
dc.subjectsleep time
dc.subjectsleep waking cycle
dc.titleSleep disorders associated with Alzheimer's disease: A perspective
dc.typeShort Survey


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