Universidad Autónoma de Chile
  • About
  • How to publish
  • Contact Us
    • Login

    Repositorio Académico

    Advanced search
    View Item 
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro

    Article
    View/Open
    item_2-s2.0-85029683735.pdf (3.976Kb)
    Date
    2018
    DOI
    10.1007/s12035-017-0771-4

    Metadata
    Show full item record
    Author
    Baez-Jurado E.
    Hidalgo-Lanussa O.
    Guio-Vega G.
    Ashraf G.M.
    Echeverria V.
    Aliev G.
    Barreto G.E.
    Abstract
    Astrocytes perform essential functions in the preservation of neural tissue. For this reason, these cells can respond with changes in gene expression, hypertrophy, and proliferation upon a traumatic brain injury event (TBI). Different therapeutic strategies may be focused on preserving astrocyte functions and favor a non-generalized and non-sustained protective response over time post-injury. A recent strategy has been the use of the conditioned medium of human adipose mesenchymal stem cells (CM-hMSCA) as a therapeutic strategy for the treatment of various neuropathologies. However, although there is a lot of information about its effect on neuronal protection, studies on astrocytes are scarce and its specific action in glial cells is not well explored. In the present study, the effects of CM-hMSCA on human astrocytes subjected to scratch assay were assessed. Our findings indicated that CM-hMSCA improved cell viability, reduced nuclear fragmentation, and preserved mitochondrial membrane potential. These effects were accompanied by morphological changes and an increased polarity index thus reflecting the ability of astrocytes to migrate to the wound stimulated by CM-hMSCA. In conclusion, CM-hMSCA may be considered as a promising therapeutic strategy for the protection of astrocyte function in brain pathologies. © 2017, Springer Science+Business Media, LLC.
    Collections
    • Artículos científicos

    Related items

    Showing items related by title, author, creator and subject.

    • Article

      Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay (2020) 

      Baez-Jurado E.; Vega G.G.; Aliev G.; Tarasov V.V.; Esquinas P.; Echeverria V.; Barreto G.E. (Humana Press Inc., 2018)
    • Article

      Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid (2020) 

      González-Giraldo Y.; Garcia-Segura L.M.; Echeverria V.; Barreto G.E. (Humana Press Inc., 2018)
    • Article

      The role of bone marrow mononuclear cell-conditioned medium in the proliferation and migration of human dermal fibroblasts (2020) 

      Menéndez-Menéndez Y.; Otero-Hernández J.; Vega J.A.; Pérez-Basterrechea M.; Pérez-López S.; Álvarez-Viejo M.; Ferrero-Gutiérrez A. (Springer International Publishing, 2017)
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección

    Browse

    All contentCollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Academic Journals
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección