Universidad Autónoma de Chile
  • About
  • How to publish
  • Contact Us
    • Login

    Repositorio Académico

    Advanced search
    View Item 
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    •   Home
    • Investigación y Desarrollo
    • Producción Científica
    • Artículos científicos
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity

    Article
    View/Open
    item_2-s2.0-85018362703.pdf (4.478Kb)
    Date
    2017
    DOI
    10.1016/j.appet.2017.04.008

    Metadata
    Show full item record
    Author
    Arguelles J.
    Perillan C.
    Beltz T.G.
    Xue B.
    Badaue-Passos D.
    Jr.
    Vega J.A.
    Johnson A.K.
    Abstract
    To examine the fetal programming effects of maternal hypertension, natriophilia and hyperreninemia [experimentally induced in rats by partial inter-renal aortic ligature (PAL) prior to mating] fos immunoreactivity was studied in 6-day-old offspring of PAL and control mothers. The purposes of the present set of experiments were twofold. The first was to characterize the effects of PAL on the mother's arterial blood pressure and intake of salt (1.8% NaCl solution) and water over the course of gestation. Second, was to study the pattern of neuronal activation in key brain areas of 6-day-old offspring treated with the dipsogen isoproterenol that were from PAL and control mothers. Beta-adrenergic receptor agonist-treated pups allowed the determination whether there were neuroanatomical correlates within the neural substrates controlling thirst and the enhanced water intake evidenced by the isoproterenol treated pups of PAL mothers. Hydromineral ingestive behavior along with blood pressure and heart rate of PAL (M-PAL) and control (M-sPAL) dams throughout gestation was studied. Higher salt and water intakes along with blood pressures and heart rates were found during gestation and lactation in the M-PAL group. Maternal PAL evoked significantly increased isoproterenol-elicited Fos staining in brain regions (e.g. subfornical organ, organum vasculosum of the lamina terminalis, supraoptic nucleus, hypothalamic paraventricular nucleus and median preoptic nucleus) of 6-day-old pups, which is the age of animals shown enhanced thirst responses in PAL offspring. These results indicate that PAL is compatible with pregnancy, producing a sustained increase in blood pressure and heart rate, along with increased water and salt intake. The present study demonstrates that the neural substrates involved in cardiovascular homeostasis and fluid balance in adult rats are responsive in six-day-old rats, and can be altered by fetal programming. © 2017 Elsevier Ltd
    Collections
    • Artículos científicos

    Related items

    Showing items related by title, author, creator and subject.

    • Article

      Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats (2020) 

      Burgos H.; Hernández A.; Constandil L.; Ríos M.; Flores O.; Puentes G.; Hernández K.; Morgan C.; Valladares L.; Castillo A.; ... (Elsevier B.V., 2019)
    • Article

      Total and fetal circulating cell-free DNA, angiogenic, and antiangiogenic factors in preeclampsia and HELLP syndrome (2020) 

      Muñoz-Hernández R.; Medrano-Campillo P.; Miranda M.L.; Macher H.C.; Praena-Fernández J.M.; Vallejo-Vaz A.J.; Dominguez-Simeon M.J.; Moreno-Luna R.; Stiefel P. (Oxford University Press, 2017)
    • Article

      Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats (2020) 

      Del Rio R.; Andrade D.C.; Lucero C.; Arias P.; Iturriaga R. (Lippincott Williams and Wilkins, 2016)
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección

    Browse

    All contentCollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Academic Journals
    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección