Potent in Vitro α-Glucosidase Inhibition of Secondary Metabolites Derived from Dryopteris cycadina
MetadataShow full item record
α-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial hyperglycemia. The present study was therefore designed to analyze the effects of various compounds isolated from Dryopteris cycadina against α-glucosidase including β-Sitosterol 1, β-Sitosterol3-O-β-D-glucopyranoside 2, 3, 5, 7-trihydroxy-2-(p-tolyl) chorman-4-one 3, Quercetin-3-0-β-D-glucopyranoside (3/→0-3///)- β-D- Quercetin -3-0- β –D-galactopyranoside 4 and 5, 7, 4/-Trihydroxyflavon-3-glucopyranoid 5. The in vitro spectrophotometric method was used for the analysis of test compounds against possible inhibition. Similarly, molecular docking studies were performed using the MOE software. These compounds showed concentration-dependent inhibition on α-glucosidase, and compounds 1 (IC50: 143 ± 0.47 µM), 3 (IC50:133 ± 6.90 µM) and 5 (IC50: 146 ± 1.93 µM) were more potent than the standard drug, acarbose (IC50: 290 ± 0.54 µM). Computational studies of these compounds strongly supported the in vitro studies and showed strong binding receptor sensitivity. In short, the secondary metabolites isolated from D. cycadina demonstrated potent α-glucosidase inhibition that were supported by molecular docking with a high docking score. © 2019 by the authors.
Showing items related by title, author, creator and subject.
Targeting α -(1,4)-glucosidase in diabetes mellitus type 2: The role of new synthetic coumarins as potent inhibitors (2020) Figueroa-Benavides C.; Matos M.J.; Peñaloza-Amion M.; Veas R.; Valenzuela-Barra G.; Zapata G.; Delogu G.; Uriarte E.; Santana L.; Olea-Azar C.; ... (Bentham Science Publishers B.V., 2018)
Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: Targeting neurological and mental disorders (2020) Dhiman P.; Malik N.; Sobarzo-Sánchez E.; Uriarte E.; Khatkar A. (MDPI AG, 2019)
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors (2020) Costas-Lago M.C.; Besada P.; Rodríguez-Enríquez F.; Viña D.; Vilar S.; Uriarte E.; Borges F.; Terán C. (Elsevier Masson SAS, 2017)