Cancer Stem Cells in Human Prostate Cancer. Role in Drug Resistance and Metastasis
Prostate cancer is one of the most important causes of oncologic death in men, and Chile has also reached that level. Prostate cancer mortality is mostly associated with metastatic disease where the cancer is usually resistant to available treatments, particularly hormone- therapy and chemotherapy. It has been suggested that the existence of cancer stem cells could account for the metastatic capacity and treatment resistance in most cancers. Recently, cells with stem characteristics have been identified in established cell lines and animal models of prostate cancer. We have isolated and characterized this kind of cells from patient tumors. This finding opens the possibility to manipulate them as potential therapeutic targets.
Showing items related by title, author, creator and subject.
ReviewReyes M.E.; Riquelme I.; Salvo T.; Zanella L.; Letelier P.; Brebi P. (MDPI AG, 2020)
Cardiorespiratory fitness and site-specific risk of cancer in men: A systematic review and meta-analysis (2020) Pozuelo-Carrascosa D.P.; Alvarez-Bueno C.; Cavero-Redondo I.; Morais S.; Lee I.M.; Martínez-Vizcaíno V. (Elsevier Ltd, 2019)
Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck (2020) García-Pedrero J.M.; Martínez-Camblor P.; Diaz-Coto S.; Munguia-Calzada P.; Vallina-Alvarez A.; Vazquez-Lopez F.; Rodrigo J.P.; Santos-Juanes J. (Mosby Inc., 2017)