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dc.creatorGonzales, Gustavo
dc.date2015-12-01
dc.identifierhttps://revistas.uautonoma.cl/index.php/ijmss/article/view/170
dc.identifier10.32457/ijmss.2015.043
dc.descriptionAdaptation or natural acclimatization results from the interaction between genetic variations and acclimatization resulting in individuals with ability to live and reproduce without problems at high altitudes. Testosterone is a hormone that increases erythropoiesis and inhibits ventilation. It could therefore, be associated to the adaptation to high altitudes. Excessive erythrocytosis, which in turn will develop chronic mountain sickness is caused by low arterial oxygen saturation and ventilatory inefficiency and blunted ventilatory response to hypoxia. Testosterone is elevated in natives at high altitude with excessive erythrocytosis (>21 g /dl hemoglobin in men and >19 g/dl in women). Natives from the Peruvian central Andes with chronic mountain sickness express gene SENP1 that enhances the activity of the androgen receptor. Results of the current investigations suggest that increase in serum testosterone and hemoglobin is not adequate for adaptation to high altitude.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidad Autónoma de Chileen-US
dc.relationhttps://revistas.uautonoma.cl/index.php/ijmss/article/view/170/167
dc.rightsCopyright (c) 2020 International Journal of Medical and Surgical Sciencesen-US
dc.sourceInternational Journal of Medical and Surgical Sciences; Vol. 2 No. 4 (2015): December 2015; 689-697en-US
dc.sourceInternational Journal of Medical and Surgical Sciences; Vol. 2 Núm. 4 (2015): December 2015; 689-697es-ES
dc.source0719-532X
dc.source0719-3904
dc.subjectHemoglobinen-US
dc.subjectTestosteroneen-US
dc.subjectErythropoiesisen-US
dc.subjectSENP1en-US
dc.subjectAdaptationen-US
dc.subjectAltitudeen-US
dc.titleImportance of Testosterone on Adaptation at High Altitudeen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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