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dc.contributor.authorRojas-Villalta, Dorian
dc.contributor.authorGómez-Espinoza, Olman
dc.contributor.authorMurillo-Vega, Francinie
dc.contributor.authorVillalta-Romero, Fabián
dc.contributor.authorGuerrero, Maritza
dc.contributor.authorGuillén-Watson, Rossy
dc.contributor.authorNúñez-Montero, Kattia
dc.date.accessioned2024-04-10T01:32:22Z
dc.date.available2024-04-10T01:32:22Z
dc.date.issued2023
dc.identifier10.3390/fermentation9110941
dc.identifier.issn23115637
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10623
dc.description.abstractMeso- and extremophilic microalgae and cyanobacteria have a wide range of biotechnological applications. However, the industrial demand for bioactive molecules and the redundancy of these molecules has resulted in a need for new methodologies for enhanced production and the discovery of specialized metabolites. Co-cultivation has been established as a promising approach to addressing these challenges. In this context, this work aimed to describe the state of the art of the co-cultivation method involving meso- and extremophilic photosynthetic microorganisms, as well as discuss the advantages, challenges, and limitations of this approach. Co-culture is defined as an ecology-driven method in which various symbiotic interactions involving cyanobacteria and microalgae can be used to explore new compounds and enhanced production. Promising results regarding new bioactive metabolite expression and increased production through co-cultivation-based research support that idea. Also, the metabolic diversity and evolutionary adaptations of photosynthetic microorganisms to thrive in extreme environments could improve the efficiency of co-cultivation by allowing the implementation of these microorganisms. However, the complexity of ecological interactions and lack of standardization for co-cultivation protocols are obstacles to its success and scientific validation. Further research in symbiotic interplays using -omics and genetic engineering, and predictive experimental designs for co-cultures are needed to overcome these limitations. © 2023 by the authors.es_ES
dc.description.sponsorshipMIDEPLAN-EU, (5402-1510-1040/9051-03); Instituto Tecnológico de Costa Rica, ITCR, (1510184 (2023); Vicerrectoría de Investigación y Extensión, Universidad Industrial de Santander, VIE, UIS; Agencia Nacional de Investigación y Desarrollo, ANID, (3230521, FONDECYT-11230475)es_ES
dc.language.isoenes_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.subjectalgaees_ES
dc.subjectbioactive metaboliteses_ES
dc.subjectco-culturees_ES
dc.subjectecological interactionses_ES
dc.subjectnew bioprospectinges_ES
dc.titleInsights into Co-Cultivation of Photosynthetic Microorganisms for Novel Molecule Discovery and Enhanced Production of Specialized Metaboliteses_ES
dc.typeArticlees_ES


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