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dc.contributor.authorOlea, Andres F.
dc.contributor.authorRubio, Julia
dc.contributor.authorSedan, Claudia
dc.contributor.authorCarvajal, Denisse
dc.contributor.authorNuñez, Maria
dc.contributor.authorEspinoza, Luis
dc.contributor.authorLlovera, Ligia
dc.contributor.authorNuñez, Gerard
dc.contributor.authorTaborga, Lautaro
dc.contributor.authorCarrasco, Héctor
dc.date.accessioned2024-04-10T01:10:45Z
dc.date.available2024-04-10T01:10:45Z
dc.date.issued2023
dc.identifier10.3390/ijms24076530
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10581
dc.description.abstractBotrytis cinerea is a phytopathogenic fungus that causes serious damage to the agricultural industry by infecting various important crops. 2-allylphenol has been used in China as a fungicide for more than a decade, and it has been shown that is a respiration inhibitor. A series of derivatives of 2-allylphenol were synthesized and their activity against B. cinerea was evaluated by measuring mycelial growth inhibition. Results indicate that small changes in the chemical structure or the addition of substituent groups in the aromatic ring induce important variations in activity. For example, changing the hydroxyl group by methoxy or acetyl groups produces dramatic increases in mycelial growth inhibition, i.e., the IC50 value of 2-allylphenol decreases from 68 to 2 and 1 μg mL−1. In addition, it was found that the most active derivatives induce the inhibition of Bcaox expression in the early stages of B. cinerea conidia germination. This gene is associated with the activation of the alternative oxidase enzyme (AOX), which allows fungus respiration to continue in the presence of respiratory inhibitors. Thus, it seems that 2-allylphenol derivatives can inhibit the normal and alternative respiratory pathway of B. cinerea. Therefore, we believe that these compounds are a very attractive platform for the development of antifungal agents against B. cinerea. © 2023 by the authors.es_ES
dc.description.sponsorshipUniversidad Autónoma de Coahuila, UAdeC, (DIUAV04-202); Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT; Agencia Nacional de Investigación y Desarrollo, ANID, (1201097)es_ES
dc.language.isoenes_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.subject2-allylphenoles_ES
dc.subjectalternative oxidase enzymees_ES
dc.subjectantifungal activityes_ES
dc.subjectAOX inhibitorses_ES
dc.subjectBotrytis cinereaes_ES
dc.titleAntifungal Activity of 2-Allylphenol Derivatives on the Botrytis cinerea Strain: Assessment of Possible Action Mechanismes_ES
dc.typeArticlees_ES


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