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dc.contributor.authorGaite, Juan J.
dc.contributor.authorSolé-Magdalena, Antonio
dc.contributor.authorGarcía-Mesa, Yolanda
dc.contributor.authorCuendias, Patricia
dc.contributor.authorMartin-Cruces, José
dc.contributor.authorGarcía-Suárez, Olivia
dc.contributor.authorCobo, Teresa
dc.contributor.authorVega, José A.
dc.contributor.authorMartín-Biedma, Benjamín
dc.date.accessioned2024-04-10T00:58:39Z
dc.date.available2024-04-10T00:58:39Z
dc.date.issued2023
dc.identifier10.1002/ar.25351
dc.identifier.issn19328486
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10539
dc.description.abstractPIEZO1 and PIEZO2 are essential components of mechanogated ion channels, which are required for mechanotransduction and biological processes associated with mechanical stimuli. There is evidence for the presence of PIEZO1 and PIEZO2 in teeth and periodontal ligaments, especially in cell lines and mice, but human studies are almost nonexistent. Decalcified permanent human teeth and mouse molars were processed for immunohistochemical detection of PIEZO1 and PIEZO2. Confocal laser microscopy was used to examine the co-localization of PIEZO 1 and PIEZO2 with vimentin (a marker of differentiated odontoblasts) in human teeth. In the outer layer of the human dental pulp, abundant PIEZO1- and PIEZO2-positive cells were found that had no odontoblast morphology and were vimentin-negative. Based on their morphology, location, and the absence of vimentin positivity, they were identified as dental pulp stem cells or pre-odontoblasts. However, in mice, PIEZO1 and PIEZO2 were ubiquitously detected and colocalized in odontoblasts. Intense immunoreactivity of PIEZO1 and PIEZO2 has been observed in human and murine periodontal ligaments. Our findings suggest that PIEZO1 and PIEZO2 may be mechanosensors/mechanotransducers in murine odontoblasts, as well as in the transmission of forces by the periodontal ligament in humans and mice. © 2023 The Authors. The Anatomical Record published by Wiley Periodicals LLC on behalf of American Association for Anatomy.es_ES
dc.description.sponsorshipGobierno del Principado de Asturias, GPA, (PA‐21‐PF‐BP20‐122)es_ES
dc.language.isoenes_ES
dc.publisherJohn Wiley and Sons Inces_ES
dc.subjectdental pulpes_ES
dc.subjecthumanes_ES
dc.subjectmechano-gated ion channelses_ES
dc.subjectmicees_ES
dc.subjectodontoblastses_ES
dc.subjectperiodontal ligamentes_ES
dc.subjectPIEZO1es_ES
dc.subjectPIEZO2es_ES
dc.titleImmunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligamentes_ES
dc.typeArticlees_ES


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