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dc.contributor.authorMartínez-Barbero, Graciela
dc.contributor.authorGarcía-Mesa, Yolanda
dc.contributor.authorCobo, Ramón
dc.contributor.authorCuendias, Patricia
dc.contributor.authorMartín-Biedma, Benjamín
dc.contributor.authorGarcía-Suárez, Olivia
dc.contributor.authorFeito, Jorge
dc.contributor.authorCobo, Teresa
dc.contributor.authorVega, José A.
dc.date.accessioned2024-04-10T00:45:33Z
dc.date.available2024-04-10T00:45:33Z
dc.date.issued2023
dc.identifier10.3390/ijms242417161
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10510
dc.description.abstractThe carotid body is a major peripheral chemoreceptor that senses changes in arterial blood oxygen, carbon dioxide, and pH, which is important for the regulation of breathing and cardiovascular function. The mechanisms by which the carotid body senses O2 and CO2 are well known; conversely, the mechanisms by which it senses pH variations are almost unknown. Here, we used immunohistochemistry to investigate how the human carotid body contributes to the detection of acidosis, analyzing whether it expresses acid-sensing ion channels (ASICs) and determining whether these channels are in the chemosensory glomic cells or in the afferent nerves. In ASIC1, ASIC2, and ASIC3, and to a much lesser extent ASIC4, immunoreactivity was detected in subpopulations of type I glomus cells, as well as in the nerves of the carotid body. In addition, immunoreactivity was found for all ASIC subunits in the neurons of the petrosal and superior cervical sympathetic ganglia, where afferent and efferent neurons are located, respectively, innervating the carotid body. This study reports for the first time the occurrence of ASIC proteins in the human carotid body, demonstrating that they are present in glomus chemosensory cells (ASIC1 < ASIC2 > ASIC3 > ASIC4) and nerves, presumably in both the afferent and efferent neurons supplying the organ. These results suggest that the detection of acidosis by the carotid body can be mediated via the ASIC ion channels present in the type I glomus cells or directly via sensory nerve fibers. © 2023 by the authors.es_ES
dc.language.isoenes_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.subjectacid-sensing ion channelses_ES
dc.subjectcarotid bodyes_ES
dc.subjectglomus cellses_ES
dc.subjecthumanes_ES
dc.subjectimmunohistochemistryes_ES
dc.subjectnerveses_ES
dc.titleAcid-Sensing Ion Channels’ Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Bodyes_ES
dc.typeArticlees_ES


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