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dc.contributor.authorRodrigo, Juan P.
dc.contributor.authorSánchez-Canteli, Mario
dc.contributor.authorOtero-Rosales, María
dc.contributor.authorMartínez-Camblor, Pablo
dc.contributor.authorHermida-Prado, Francisco
dc.contributor.authorGarcía-Pedrero, Juana M.
dc.date.accessioned2024-04-09T22:28:32Z
dc.date.available2024-04-09T22:28:32Z
dc.date.issued2024
dc.identifier10.1186/s12967-024-04937-x
dc.identifier.issn14795876
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10305
dc.description.abstractBACKGROUND: Tumor mutational burden (TMB) has been demonstrated to predict the response to immune checkpoint inhibitors (ICIs) in various cancers. However, the role of TMB in head and neck squamous cell carcinoma (HNSCC) has not yet been specifically addressed. Since HNSCC patients exhibit a rather limited response to ICIs, there is an unmet need to develop predictive biomarkers to improve patient selection criteria and the clinical benefit of ICI treatment. METHODS: We conducted a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. HNSCC cohort studies were selected when TMB prior to ICI treatment was evaluated, TMB cutoff value was available, and the prognostic value of TMB was evaluated by time-to-event survival analysis. A total of 11 out of 1960 articles were analyzed, including 1200 HNSCC patients. RESULTS: The results showed that those patients harboring high TMB exhibited a significantly superior overall response rate (OR = 2.62; 95% CI 1.74-3.94; p < 0.0001) and a survival advantage (HR = 0.53; 95% CI 0.39-0.71; p < 0.0001) after ICI treatment. CONCLUSION: This is the first meta-analysis to demonstrate a higher response and clinical benefit from ICI therapy in HNSCC patients with high TMB. © 2024. The Author(s).es_ES
dc.language.isoenes_ES
dc.subjectHead and neck squamous cell carcinomaes_ES
dc.subjectImmune checkpoint inhibitorses_ES
dc.subjectMeta-analysises_ES
dc.subjectTumor mutational burdenes_ES
dc.titleTumor mutational burden predictability in head and neck squamous cell carcinoma patients treated with immunotherapy: systematic review and meta-analysises_ES
dc.typeArticlees_ES


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