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Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
Down syndrome
mTOR
Oxidative stress
Protein-bound HNE
Rapamycin
4 hydroxynonenal
arginase
arginase 1
mammalian target of r...
phosphoprotein phosph...
rapamycin
tau protein
biological marker
proteasome
rapamycin
target of rapamycin k...
Alzheimer disease
amnesia
animal experiment
animal model
animal tissue
antioxidant activity
Article
brain protection
controlled study
dose response
Down syndrome
enzyme activity
enzyme inhibition
female
lipid peroxidation
male
mouse
mouse model
mTOR signaling
nonhuman
oxidation
oxidative stress
priority journal
protein analysis
protein phosphorylati...
proteomics
spatial memory
synaptic transmission...
treatment duration
animal
autophagy
disease model
drug effect
intranasal drug admin...
metabolism
procedures
signal transduction
Administration, Intra...
Animals
Autophagy
Biomarkers
Disease Models, Anima...
Down Syndrome
Female
Male
Mice
Oxidative Stress
Proteasome Endopeptid...
Proteomics
Signal Transduction
Sirolimus
TOR Serine-Threonine ...