Increased mammalian target of rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of down's syndrome

Alzheimer's disease

Autophagy

Down's syndrome

Mammalian target of r...

Protein oxidation

4 hydroxynonenal

mammalian target of r...

rapamycin

MTOR protein, human

mTOR protein, mouse

target of rapamycin k...

animal cell

animal experiment

animal model

autophagosome

autophagy

cell viability

Conference Paper

controlled study

Down syndrome

female

male

mouse

MTT assay

neuroblastoma cell

nonhuman

oxidation

oxidative stress

priority journal

protein phosphorylati...

reciprocal chromosome...

signal transduction

trisomy

Western blotting

animal

C3H mouse

C57BL mouse

disease model

Down syndrome

hippocampus

human

metabolism

oxidation reduction r...

phosphorylation

signal transduction

transgenic mouse

tumor cell line

Animals

Blotting, Western

Cell Line, Tumor

Disease Models, Anima...

Down Syndrome

Hippocampus

Humans

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Transgenic

Oxidation-Reduction

Phosphorylation

Signal Transduction

Sirolimus

TOR Serine-Threonine ...