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Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction
Alzheimer's disease
Blood-brain barrier
Mitochondriotropic an...
Neuroprotection
2 (3,4,5 trihydroxyph...
3 (3,4 dihydroxypheny...
3 (3,4,5trihydroxyphe...
3,4 dihydroxyphenylac...
3,4,5 trihydroxycinna...
acetic acid derivativ...
antioxidant
bromide
caffeic acid
gallic acid
hydrocinnamic acid de...
hydrogen peroxide
neuroprotective agent...
oxidopamine
propionic acid deriva...
protocatechuic acid
pyrogallol
reactive oxygen metab...
triton x 100
trolox C
unclassified drug
[10 [2 (3,4 dihydroxy...
[10 [2 (3,4,5 trihydr...
[10 [3 (3,4 dihydroxy...
[10 [3 (3,4,5 trihydr...
[6 [2 (3,4 dihydroxyp...
[6 [2 (3,4,5 trihydro...
[6 [3 (3,4 dihydroxyp...
[6 [3 (3,4,5 trihydro...
antioxidant
neuroprotective agent...
ABTS radical scavengi...
antioxidant activity
Article
blood brain barrier
cell viability
concentration respons...
controlled study
disorders of mitochon...
DPPH radical scavengi...
drug cytotoxicity
drug design
drug targeting
EC50
hCMEC/D3 cell line
Hep-G2 cell line
human
human cell
IC50
iron chelation
lipophilicity
mitochondrion
MTT assay
neuropharmacology
neuroprotection
neurotoxicity
nucleophilicity
oxidation reduction p...
oxidative stress
partition coefficient...
resazurin assay
SH-SY5Y cell line
substitution reaction...
Alzheimer disease
antagonists and inhib...
blood brain barrier
cell line
disorders of mitochon...
drug effect
metabolism
pathology
pathophysiology
synthesis
tumor cell line
Alzheimer Disease
Antioxidants
Blood-Brain Barrier
Cell Line
Cell Line, Tumor
Humans
Hydrogen Peroxide
Mitochondrial Disease...
Neuroprotective Agent...
Oxidative Stress
Oxidopamine