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Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease
AChE
Alzheimer's disease
Dual-active compounds...
Indole derivatives
Multitarget
SERT
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (1h indol 3 y...
1 [4 [3 (5 fluoro 1h ...
1 [4 [3 (5 fluoro 1h ...
1 [4 [3 (5 fluoro 1h ...
2 (4 benzoylpiperazin...
2 [4 (4 bromobenzoyl)...
2 [4 (4 chlorobenzoyl...
cholinesterase inhibi...
piperazine derivative...
tert butyl 4 [2 (4 be...
tert butyl 4 [2 [4 (2...
tert butyl 4 [2 [4 (3...
tert butyl 4 [2 [4 (3...
tert butyl 4 [2 [4 (3...
tert butyl 4 [2 [4 (4...
tert butyl 4 [2 [4 (4...
tert butyl 4 [2 [4 (4...
tert butyl 4 [2 [4 (4...
tert butyl 4 [2 [4 (4...
unclassified drug
unindexed drug
Alzheimer disease
animal cell
Article
carbon nuclear magnet...
cell viability
cholinesterase inhibi...
controlled study
drug synthesis
HEK293 cell line
human
human cell
hydrogen bond
IC50
in vitro study
molecular docking
mouse
Neuro-2a cell line
nonhuman
proton nuclear magnet...
SH-SY5Y cell line